Table 2.

Breast cancer risk with FOK1 and BSM1 polymorphism

FOK1 polymorphism (cases/controls)FFFfff
All women (1,234 cases/1,676 controls)
    Simple1.0 (ref)1.14 (0.97-1.34)1.36 (1.08-1.71)
    Multivariate1.0 (ref)1.13 (0.95-1.33)1.34 (1.06-1.69)
Menopausal status at blood draw*
    Postmenopausal (842/1,218)1.0 (ref)1.04 (0.85-1.27)1.25 (0.94-1.66)
    Premenopausal (261/310)1.0 (ref)1.52 (0.96-2.41)2.18 (1.18-4.00)
Invasive cancer only (1,018/1,676)1.0 (ref)1.11 (0.93-1.32)1.23 (0.97-1.57)
ER/PR status of cancers
    ER+/PR+ (601/1,676)1.0 (ref)1.07 (0.87-1.32)1.30 (0.98-1.73)
    ER−/PR− (158/1,676)1.0 (ref)1.17 (0.80-1.71)1.54 (0.96-2.49)
BSM1 polymorphism (cases/controls)
bb
Bb
BB
All women (1,180/1,547)
    Simple1.0 (ref)1.04 (0.87-1.24)0.92 (0.72-1.18)
    Multivariate1.0 (ref)1.05 (0.88-1.26)0.93 (0.72-1.20)
Menopausal status at blood draw*
    Postmenopausal (821/1,115)1.0 (ref)1.05 (0.85-1.29)0.94 (0.69-1.26)
    Premenopausal (239/298)1.0 (ref)1.01 (0.65-1.58)0.92 (0.46-1.85)
Invasive cancer only (970/1,547)1.0 (ref)1.07 (0.89-1.28)0.87 (0.68-1.13)
ER/PR status of cancers
    ER+/PR+ (574/1,547)1.0 (ref)1.04 (0.84-1.29)0.94 (0.69-1.27)
    ER−/PR− (153/1,547)1.0 (ref)1.11 (0.77-1.61)0.72 (0.40-1.28)
  • NOTE: All OR's presented in this table are multivariate (adjusted for matching factors and body mass index, parity/age at first birth, family history of breast cancer in first-degree relative, benign breast disease, alcohol consumption, age at menarche, age at menopause), except those marked “Simple” which were adjusted only for matching factors (age, menopausal status, postmenopausal hormone use, fasting status, and month, day, and time of blood draw).

  • * Women with an unknown menopausal status were excluded from the subanalysis by menopausal status.