Table 3.

ORs for number of variant genotypes in DSB repair genes and breast cancer in African Americans and Whites

Genotype combinationCases/controlsOR* (95% CI)
African Americans
    0 variants193/183Reference
    1 variant343/2931.1 (0.8-1.4)
    2 variants168/1621.0 (0.7-1.4)
    3 variants36/301.1 (0.6-1.9)
    4 variants1/20.6 (0.1-6.4)
Whites
    0 variants111/88Reference
    1 variant375/3390.8 (0.6-1.2)
    2 variants494/4490.8 (0.6-1.1)
    3 variants232/2330.7 (0.5-1.0)
    4 variants31/201.1 (0.6-2.1)
  • * Adjusted for offsets and age.

  • Variant genotypes: XRCC3 codon 241 any Met, NBS1 codon 185 any Gln, XRCC2 codon 188 any His, and BRCA2 codon 372 any His.

  • Imprecise estimate.