Table 2.

Genotype frequencies, allele frequencies, and ORs for DSB repair gene polymorphisms and breast cancer in African-American and White women

LocusAfrican Americans
Whites
Cases (n = 768)Controls (n = 681)OR* (95% CI)Cases (n = 1,277)Controls (n = 1,137)OR* (95% CI)
XRCC3 codon 241
    Thr/Thr482 (65)421 (62)Reference505 (40)435 (38)Reference
    Thr/Met222 (30)211 (31)0.9 (0.7-1.0)578 (46)555 (49)0.9 (0.7-1.0)
    Met/Met41 (5)44 (7)0.7 (0.5-1.2)171 (14)142 (13)1.0 (0.8-1.4)
Missing2345135
Cochrane-Armitage test (P)0.290.79
Thr§0.80 (0.78-0.82)0.78 (0.76-0.80)0.63 (0.61-0.65)0.63 (0.61-0.65)
Met0.20 (0.18-0.22)0.22 (0.20-0.23)0.37 (0.35-0.39)0.37 (0.35-0.39)
χ2 test (P)0.260.79
NBS1 codon 185
    Glu/Glu440 (57)400 (59)Reference588 (46)518 (46)Reference
    Glu/Gln287 (38)240 (35)1.1 (0.9-1.4)566 (45)503 (44)1.0 (0.8-1.2)
    Gln/Gln39 (5)41 (6)0.9 (0.5-1.4)119 (9)115 (10)0.8 (0.6-1.1)
Missing2041
χ2 test (P)0.560.81
Glu§0.76 (0.74-0.78)0.76 (0.74-0.79)0.68 (0.67-0.70)0.68 (0.66-0.69)
Gln0.24 (0.22-0.26)0.24 (0.21-0.26)0.32 (0.30-0.33)0.32 (0.30-0.34)
χ2 test (P)0.910.61
XRCC2 codon 188
    Arg/Arg744 (97)653 (96)Reference1,084 (85)982 (86)Reference
    Arg/His21 (3)25 (4)0.7 (0.4-1.3)176 (14)145 (13)1.0 (0.8-1.3)
    His/His00ND8 (1)7 (1)0.7 (0.2-1.9)
Missing3393
χ2 test (P)0.310.73
Arg§0.99 (0.98-0.99)0.98 (0.97-0.99)0.92 (0.91-0.93)0.93 (0.92-0.94)
His0.01 (0.0-0.02)0.02 (0.01-0.03)0.08 (0.07-0.09)0.07 (0.06-0.08)
χ2 test (P)0.310.46
BRCA2 codon 372
    Asn/Asn564 (74)510 (76)Reference662 (52)579 (51)Reference
    Asn/His183 (24)153 (23)1.2 (0.9-1.5)521 (41)467 (41)1.0 (0.8-1.2)
    His/His15 (2)12 (2)1.3 (0.6-2.8)82 (7)89 (8)0.8 (0.6-1.2)
Missing66122
χ2 test (P)0.790.42
Asn§0.86 (0.84-0.88)0.87 (0.85-0.89)0.73 (0.71-0.75)0.72 (0.70-0.73)
His0.14 (0.14-0.16)0.13 (0.12-0.15)0.27 (0.25-0.29)0.28 (0.27-0.30)
χ2 test (P)0.500.30
  • * Adjusted for offsets and age.

  • Genotype frequencies n (%). ND, not determined.

  • Comparing cases and controls.

  • § Allele frequencies (95% CI).