Table 2.

Age-adjusted and race/ethnicity–adjusted LS mean levels for IGF-I, IGFBP-3, and IGFMR by sex, race/ethnicity, age, height, BMI, parity, and lifestyle variables

Females
Males
VariableIGF-IIGFBP-3IGFMRVariableIGF-IIGFBP-3IGFMR
Race/ethnicityNative Hawaiian144.82,8470.19Native Hawaiian190.12,7090.26
African American154.42,5860.22African American176.52,3790.28
Japanese148.52,9340.19Japanese180.02,6780.25
Latino122.82,2340.20Latino169.32,5200.25
White143.82,8360.19White180.42,7940.24
P*0.003<0.00010.57P*0.480.0110.10
Age, yQ1<61150.42,9560.19Q1<57189.12,8510.25
Q261–67156.22,8580.20Q257–64197.72,7720.27
Q368–72132.92,4610.20Q365–71166.72,5380.24
Q473+131.92,4610.20Q472+165.32,3190.27
P0.001<0.00010.24P0.001<0.00010.23
Height, in.Q1<61136.025920.20Q1<66159.323400.25
Q261–62144.227470.20Q266–67171.325500.25
Q363–64147.626930.20Q368–69176.227700.24
Q465+141.826630.20Q470+195.826680.27
P0.720.930.73P0.0060.020.24
BMI, kg/m2Q1<23149.62,5790.22Q1<24192.72,7110.26
Q223–25155.12,9280.20Q224–26180.92,6130.26
Q326–29144.22,7920.19Q327–28177.92,6390.25
Q430+126.82,4770.19Q429+168.92,5240.25
P0.030.310.06P0.100.360.27
Parity0–2 Children146.22,7310.20
3–4 Children142.72,6710.20
5+ Children137.32,5950.20
P*0.530.570.95
Physical activity, h/wk vigorous work0145.22,7020.200180.22,5870.26
>0134.72,5960.19>0178.32,6320.25
P*0.130.330.49P*0.810.610.44
SmokingNever144.32,6350.20Never179.02,6280.25
Past135.52,6890.19Past186.02,6060.27
Current151.12,7990.20Current155.82,5630.23
P*0.200.400.18P*0.010.880.005
Energy intake, kcal/dQ1<1,333136.22,5780.20Q1<1,591174.22,6380.25
Q21,333–1,812142.92,7840.19Q21,591–2,257177.72,4810.27
Q31,813–2,441142.62,6850.20Q32,258–2,894175.22,6020.25
Q42,442+148.22,6550.21Q42895+189.72,7290.26
P0.220.920.17P0.090.110.62
Alcohol intake density, g/1,000 kcal/dQ1<0.00015139.22,4950.21Q1<0.0002188.12,6090.27
Q20.00015–0.00032139.72,5450.20Q20.00021–0.0763177.62,4950.26
Q30.00033–0.0684138.42,7400.19Q30.07631–0.5555176.92,5590.26
Q40.0685+152.22,9070.20Q40.5556+169.72,7030.23
P0.340.0030.24P0.360.330.02
Total fat intake density, g/1,000 kcal/dQ1<23144.02,6330.20Q1<29185.42,8760.24
Q223–27139.82,6530.20Q229–34183.12,6010.26
Q328–38142.52,7210.20Q335–39178.42,4610.27
Q439+143.32,6220.20Q440+170.32,5280.25
P0.730.800.61P0.150.0010.18
Saturated fat intake density, g/1,000 kcal/dQ1<7138.82,7640.19Q1<8184.22,8770.24
Q27–9146.42,6540.21Q28–9181.12,5890.26
Q310–11143.72,7480.19Q310–11176.92,5600.26
Q412+138.72,5720.20Q412+175.32,4800.26
P0.530.160.75P0.230.010.25
Fat from meat intake density, g/1,000 kcal/dQ1<2.68146.82,8180.19Q1<3.58183.92,7340.25
Q22.68–4.59140.52,6450.20Q22.58–5.88188.02,6110.27
Q34.60–6.92141.12,6010.20Q35.89–8.12178.62,6260.25
Q46.93+141.62,6430.20Q48.13+167.12,4850.25
P0.430.060.37P0.0010.0030.28
Total protein intake density, g/1,000 kcal/dQ1<33140.42,7070.19Q1<33169.92,6920.23
Q233–36145.42,6870.20Q233–36202.72,7590.27
Q337–40146.02,6610.20Q337–40175.62,5570.26
Q441+139.32,6510.20Q441+173.22,4730.26
P0.690.980.57P0.600.050.23
Total dairy intake density, g/1,000 kcal/dQ1<51138.92,6640.19Q1<35168.52,5870.24
Q251–98141.92,6340.20Q235–73181.12,6120.26
Q399–156139.92,6120.20Q373–142184.32,5680.27
Q4157+149.42,7920.20Q4143+183.32,6840.25
P0.480.270.86P0.410.240.91
Total milk intake density, g/1,000 kcal/dQ1<19138.02,6230.20Q1<16163.52,6220.23
Q219–63137.12,5470.20Q216–44185.22,4780.28
Q364–119141.02,6710.20Q345–103187.32,6710.26
Q4120+154.32,8680.20Q4104+182.02,6850.25
P0.270.090.84P0.660.160.42
Total low-fat milk intake density, g/1,000 kcal/dL10140.42,6740.19L10178.52,6930.25
L21–15.5137.72,6840.19L21–9.92185.32,6130.26
L315.54–48.74143.42,6100.20L39.93–35.19186.92,4630.28
L448.75–98.12146.52,6210.21L435.20–83.04166.62,3940.26
L598.13+151.92,7930.20L583.05+180.22,6490.25
P0.200.740.18P0.820.110.22
Vitamin D intake density from food sources, g/1,000 kcal/dQ1<38139.02,6360.20Q1<33173.62,6580.24
Q238–64141.62,6900.19Q233–58173.02,5900.25
Q365–89141.72,6100.20Q359–85183.32,5050.27
Q490+147.42,7600.20Q486+187.52,7010.26
P0.140.120.73P0.320.670.43
Calcium intake density from food sources, g/1,000 kcal/dQ1<308139.72,6420.20Q1<262165.42,6110.24
Q2308–389137.82,6540.19Q2262–333183.12,5680.27
Q3390–483147.82,6960.20Q3334–429185.32,6170.26
Q4484+144.92,7070.20Q4430+184.12,6530.26
P0.430.340.93P0.380.660.52
  • NOTE: The means presented are LS means of natural log-transformed hormone levels exponentiated back to physiologic levels.

  • * P for homogeneity, categorical variable.

  • P for trend, continuous variable.