Table 1.

Frequency, RR, and 95% CI for IL-2 and IL-10 SNPs

GenotypeSubcohort* [n (%)]GCC
ESCC
n (%)Relative risk95% Confidence intervalP2 dfn (%)Relative risk95% Confidence intervalP2 df
IL-2 −384
    G/G96 (25.3)16 (19.3)1.00Reference0.0835 (31.5)1.00Reference0.41
    G/T174 (45.9)47 (56.6)1.91(1.01–3.63)43 (38.7)0.69(0.40–1.19)
    T/T109 (28.8)20 (24.1)1.21(0.58–2.51)33 (29.7)0.83(0.46–1.48)
IL-2 +114
    G/G149 (39.5)33 (40.2)1.00Reference0.4944 (39.6)1.00Reference0.93
    G/T148 (39.3)35 (42.7)1.18(0.69–2.01)41 (36.9)1.05(0.64–1.73)
    T/T80 (21.2)14 (17.1)0.77(0.38–1.55)26 (23.4)1.12(0.62–2.01)
IL-10 −1082
    G/G284 (73.8)60 (71.4)1.00Reference0.5781 (70.4)1.00Reference0.44
    G/A81 (21.0)20 (23.8)1.28(0.72–2.27)26 (22.6)1.32(0.78–2.25)
    A/A20 (5.2)4 (4.8)0.74(0.24–2.26)8 (7.0)1.48(0.59–3.72)
IL-10 −819
    T/T170 (44.5)37 (44.1)1.00Reference0.6453 (45.7)1.00Reference0.72
    T/C163 (42.7)38 (45.2)0.92(0.55–1.54)46 (40.0)0.83(0.52–1.34)
    C/C49 (12.8)9 (10.7)0.68(0.30–1.51)17 (15.0)1.00(0.52–1.94)
IL-10 −592
    C/C171 (44.3)36 (42.9)1.00Reference0.7051 (42.9)1.00Reference0.95
    C/A166 (43.0)39 (46.4)0.95(0.57–1.59)51 (42.9)0.96(0.60–1.54)
    A/A49 (12.7)9 (10.7)0.71(0.31–1.58)17 (14.3)1.07(0.55–2.08)
  • * The subcohort was tested by χ2 to determine if the population meets the assumption of Hardy-Weinberg equilibrium for each: IL-2 −384, P = 0.12; IL-2 +114, P < 0.01; IL-10 −1082, P ≤ 0.01; IL-10 −819, P = 0.32; IL-10 −592, P = 0.38.

  • Relative risks and 95% confidence intervals were generated from models stratified on age and sex with additional adjustment from continuous age variables for each stratum and variables for smoking, drinking, and trial.

  • This P comes from the score test for the addition of all the genotype indicator variables to the base model simultaneously. It assesses the overall association between genotype and cancer.