NAT2 allele distribution among controls from case-control studies of breast, prostate, and stomach cancers
| Allele | Nucleotide substitution(s) | Breast, n = 387 [n Alleles (%)] | Stomach, n = 414 [n Alleles (%)] | Prostate, n = 149 [n Alleles (%)] |
|---|---|---|---|---|
| NAT2*4 | None | 187 (24.2) | 219 (26.4) | 64 (21.5) |
| NAT2*5A | T341C, C481T | 20 (2.6) | 7 (0.85) | 5 (1.7) |
| NAT2*5B | T341C, C481T, A803G | 318 (41.1) | 309 (37.3) | 104 (34.9) |
| NAT2*5C | T341C, A803G | 17 (2.2) | 17 (2.1) | 9 (3.0) |
| NAT2*5D | T341C | — | — | — |
| NAT2*5E | T341C, G590A | — | — | 1 (0.34) |
| NAT2*5F | T341C, C481T, C759T, A803G | — | — | — |
| NAT2*6A | C282T, G590A | 206 (26.6) | 251 (30.3) | 66 (22.1) |
| NAT2*6B | G590A | — | 1 (0.12) | 1 (0.34) |
| NAT2*6C | C282T, G590A, A803G | — | — | — |
| NAT2*6D | T111C, C282T, G590A | — | — | — |
| NAT2*7A | G857A | — | — | — |
| NAT2*7B | C282T, G857A | 15 (1.9) | 19 (2.3) | 8 (2.7) |
| NAT2*10 | G499A | ND | ND | ND |
| NAT2*11 | C481T | — | — | — |
| NAT2*12A | A803G | 3 (0.4) | 4 (0.48) | 6 (2.0) |
| NAT2*12B | C282T, A803G | — | — | 4 (1.3) |
| NAT2*12C | C481T, A803G | — | — | 2 (0.67) |
| NAT2*13 | C282T | 7 (0.9) | 1 (0.12) | 14 (4.7) |
| NAT2*14A | G191A | — | — | 3 (1.0) |
| NAT2*14B | G191A, C282T | 1 (0.1) | — | 11 (3.7) |
| NAT2*14C | G191A, T341C, C481T, A803G | — | — | — |
| NAT2*14D | G191A, C282T, G590A | — | — | — |
| NAT2*14E | G191A, A803G | — | — | — |
| NAT2*14F | G191A, T341C, A803G | — | — | — |
| NAT2*14G | G191A, C282T, A803G | — | — | — |
| NAT2*17 | A434C | — | — | — |
| NAT2*18 | A845C | — | — | — |
| NAT2*19 | C190T | ND | ND | ND |
NOTE: Alleles were assigned using a PCR-based assay that detects 11 SNPs and can therefore distinguish among 26 NAT2 allele variants. Alleles in boldface are high-activity (rapid) alleles, whereas all others are low-activity (slow) alleles. “Intermediate” acetylator phenotype is assigned when an individual possesses one “slow” and one “rapid” allele. It should be noted that NAT2*10 phenotype is unknown. ND, Our assay does not detect the G499A or C190T SNPs and thus cannot distinguish these alleles.