Table 4.

Frequency of methylation at CpGs in each of six selected genes measured in fecal DNA from healthy volunteers, patients with current or previously removed polyps, and patients with colorectal carcinoma

DiagnosisGene locus
ESR1 (132)ESR1 (195)ESR1 (281)MGMT (48)HPP1 (108)p16 (100)APC (166)MLH1 (123)
Normal (n = 21)42.8 ± 0.936.8 ± 0.438.5 ± 0.720.4 ± 1.81.5 ± 0.81.1 ± 0.41.7 ± 0.20.6 ± 0.4
Polyps (n = 10)42.3 ± 0.934.4 ± 1.638.3 ± 1.114.6 ± 2.32.8 ± 2.31.0 ± 0.51.8 ± 0.3ND
Cancer (n = 12)44.2 ± 1.333.6 ± 0.939.1 ± 1.414.1 ± 2.51.8 ± 1.02.1 ± 1.21.6 ± 0.50.7 ± 0.7
  • NOTE: Values are means and SEM of percentage values. ND, not determined.