Table 3.

Analysis of common haplotypes in the IGFBP3 gene: frequency estimates and ORs for their associations with breast cancer risk, the Shanghai Breast Cancer Study

Haplotypes*All subjects
Age < 45 y
Age ≥ 45 y
Case patients (%)Control subjects (%)OR (95% CI)Case patients (%)Control subjects (%)OR (95% CI)Case patients (%)Control subjects (%)OR (95% CI)
A, G, C, N, C71.7073.701.0 (reference)72.1374.631.0 (reference)71.4173.031.0 (reference)
A, G, C, A, T2.803.190.9 (0.6-1.3)2.313.130.7 (0.4-1.3)3.153.231.0 (0.7-1.6)
C, C, C, A, T17.9217.461.0 (0.9-1.2)17.1616.771.1 (0.8-1.4)18.4317.961.1 (0.9-1.3)
C, C, G, A, T3.482.641.4 (1.0-1.9)4.522.052.3 (1.3-3.9)2.783.060.9 (0.6-1.5)
No. of chromosomes2,1782,3508849761,2941,374
  • * From left, the polymorphic sites are A−202C, G227C, C3804G, 5606InsA, and C5827T. N, no insertion at nucleotide 5606.