Table 2.

IGFBP3 allele and genotype frequencies and ORs (95% CIs) for breast cancer risk, the Shanghai Breast Cancer Study

PolymorphismGenotypesCase patientsControl subjectsOR* (95% CI)OR (95% CI)
A−202CAA6417081.0 (reference)1.0 (reference)
AC4054551.0 (0.8-1.2)1.0 (0.8-1.2)
CC63441.6 (1.1-2.4)1.6 (1.0-2.3)
G227CGG6537391.0 (reference)1.0 (reference)
GC3914301.0 (0.9-1.2)1.0 (0.9-1.2)
CC63421.7 (1.1-2.5)1.6 (1.1-2.5)
C3804GCC1,0511,1671.0 (reference)1.0 (reference)
GC84691.4 (1.0-1.9)1.3 (0.9-1.9)
GG00
5606InsANN5966551.0 (reference)1.0 (reference)
NA4475021.0 (0.8-1.2)1.0 (0.8-1.2)
AA78581.4 (1.0-2.1)1.4 (1.0-2.1)
C5827TCC6116691.0 (reference)1.0 (reference)
CT4464881.0 (0.9-1.2)1.0 (0.8-1.2)
TT72581.3 (0.9-1.9)1.3 (0.9-1.9)
All women
Presence of any risk genotypes§
    No9411,0611.0 (reference)1.0 (reference)
    Yes1481141.4 (1.1-1.9)1.4 (1.0-1.8)
No. of risk genotypes
    1-290751.3 (1.0-1.8)1.3 (0.9-1.8)
    3-558391.7 (1.1-2.5)1.6 (1.1-2.5)
P for trend0.010.01
Stratified analyses by age
Women <45 y
Presence of any risk genotypes
    No3764421.0 (reference)1.0 (reference)
    Yes66461.6 (1.1-2.5)1.7 (1.1-2.5)
Women ≥45 y
Presence of any risk genotypes
    No5656191.0 (reference)1.0 (reference)
    Yes82681.3 (0.9-1.9)1.2 (0.9-1.8)
  • * OR adjusted for age.

  • OR adjusted for age, physical activity, waist-to-hip ratio, body mass index, age at menarche, nulliparity, age at first live birth, and menopausal status.

  • N, no insertion.

  • § Risk genotypes include CC at A−202C, CC at G227C, CG at C3804G, AA at 5606InsA, and TT at C5827T.