Table 3.

IRRs of second primary cancer according to XPD genotype and cigarette smoking status in a cohort of individuals with a history of NMSC, Washington County, Maryland, 1989 to 2002

Smoking status*XPD genotypesDeveloped second primary cancer
Incident cases per 100 person-yearsMultivariate adjusted IRR (95% CI)
Yes, n (%)No, n (%)
NeverLys/Lys4 (5.0)83 (20.7)0.401.00 (reference)
Lys/Gln and Gln/Gln24 (30.0)119 (29.7)1.523.93 (1.36-11.36)
EverLys/Lys14 (17.5)77 (19.3)1.423.51 (1.14-10.80)
Lys/Gln and Gln/Gln38 (47.5)121 (30.3)2.306.14 (2.17-17.37)
  • * Data missing for one participant for cigarette smoking status.

  • Adjusted for age at diagnosis of NMSC, sex, and years of education in 1989.