Table 2.

IRRs of second primary cancer by XPD genotype in a cohort of individuals with a history of NMSC, Washington County, Maryland, 1989 to 2002

XPD genotypesDeveloped second primary cancer
Incident cases per 100 person-yearsAge-adjusted IRR (95% CI)Multivariate adjusted IRR* (95% CI)
No, n (%)Yes, n (%)
Lys/Lys160 (39.9)18 (22.5)0.921.00 (reference)1.00 (reference)
Lys/Gln184 (45.9)51 (63.8)2.102.27 (1.32-3.89)2.27 (1.32-3.91)
Gln/Gln57 (14.2)11 (13.7)1.501.87 (0.88-3.98)1.98 (0.93-4.21)
Lys/Gln and Gln/Gln1.962.19 (1.29-3.70)2.22 (1.30-3.76)
  • * Adjusted for age at NMSC diagnosis, sex, years of education in 1989, and cigarette smoking status in 1989 (never, former, or current).