Table 3.

Aggressiveness-stratified ORs for relation between MTHFR C677T and A1298C genotypes/haplotypes and prostate cancer

MTHFR VariantLow aggressive*
High aggressive
Cases/ControlsOR (95% CI)PCases/ControlsOR (95% CI)P
C677T genotype
    CC (reference)87/1061.0 (reference)119/1021.0
    CT77/761.85 (0.99-3.46)0.0589/1040.55 (0.34-0.88)0.01
    TT24/252.01 (0.69-5.85)0.2017/340.22 (0.08-0.61)0.004
    CT or TT1.86 (1.00-3.46)0.050.51 (0.32-0.82)0.01
A1298C genotype
    AA (reference)89/1031.093/1181.0
    AC81/831.34 (0.71-2.54)0.36113/981.81 (1.07-3.05)0.03
    CC18/211.00 (0.35-2.86)1.0019/231.01 (0.36-2.88)0.98
    AC or CC1.32 (0.70-2.50)0.391.79 (1.06-3.02)0.03
Haplotypes§
    677C-1298A (reference)135/1641.0176/1621.0
    677C-1298C116/1241.49 (0.85-2.61)0.17149/1440.87 (0.50-1.49)0.61
    677T-1298A124/1251.84 (1.07-3.16)0.03123/1720.47 (0.29-0.76)0.002
  • * Includes cases with Gleason score <7 and/or tumor stage <T2C and their brothers.

  • Includes cases with Gleason score ≥7 and/or tumor stage ≥T2C and their brothers.

  • Adjusted for age, folate intake, calories, alcohol consumption, pack-years smoking, and body mass index (all continuous).

  • § Counts reflect haplotypes. There is one case and one control with the 677T-1298C haplotype for Low Aggressive.