Table 2.

Association between MTHFR C677T and A1298C genotypes/haplotypes and prostate cancer risk

MTHFR VariantCases/ControlsCrude*
Adjusted
OR (95% CI)POR (95% CI)P
C677T genotype
    CC (reference)214/2191.0 (reference)1.0
    CT182/1990.96 (0.68-1.37)0.830.90 (0.63-1.29)0.57
    TT43/610.70 (0.36-1.36)0.290.67 (0.34-1.32)0.24
    CT or TT0.94 (0.66-1.33)0.730.88 (0.62-1.26)0.49
A1298C genotype
    AA (reference)195/2331.01.0
    AC205/2011.44 (0.99-2.09)0.051.42 (0.97-2.09)0.07
    CC39/441.04 (0.52-2.11)0.911.07 (0.52-2.18)0.86
    AC or CC1.42 (0.98-2.05)0.061.41 (0.96-2.06)0.08
Haplotypes
    677C-1298A (reference)330/3491.01.0
    677C-1298C280/2881.17 (0.81-1.67)0.411.12 (0.77-1.63)0.54
    677T-1298A267/3200.95 (0.68-1.34)0.780.90 (0.63-1.27)0.54
  • * Crude: regression model includes age (continuous).

  • Adjusted for age, folate intake, calories, alcohol consumption, pack-years smoking, and body mass index (all continuous).

  • Counts reflect the number of chromosomes. There is one case and one control with the 677T-1298C haplotype.