Table 1.

Characteristics of the family-based case-control study population including MTHFR genotype and haplotype counts

Cases (n = 439)Controls (n = 479)
Age (y), mean (SD)61.0 (6.7)62.7 (9.1)
Ethnicity, n (%)
    Caucasian397 (90)437 (91)
    African American38 (9)38 (8)
    Other5 (1)5 (1)
Genotypes, n (%)
    677 CC214 (49)219 (46)
    677 CT182 (41)199 (41)
    677 TT43 (10)61 (13)
    1298 AA195 (44)233 (49)
    1298 AC205 (47)201 (42)
    1298 CC39 (9)44 (9)
Haplotypes, n (%)*
    677C-1298A330 (38)349 (36)
    677C-1298C280 (32)288 (30)
    677T-1298A267 (30)320 (33)
    677T-1298C1 (0.1)1 (0.1)
  • * Counts reflect the number of chromosomes.