Table 2.

The fits for log-log age-specific rate regression models with one change-point to the SEER incidence rates for each histopathologic subtype

Histopathologic typeAge of change-point*Slope before changeSlope after changeP value
All cases combined
Total525.71.8<0.0001
ERP526.42.1<0.0001
ERN524.90.30.1077
Duct NST
Total525.61.7<0.0001
ERP526.22.0<0.0001
ERN524.80.30.1607
Tubular
Total528.41.7<0.0001
ERP528.81.8<0.0001
ERN574.60.70.2077
Lobular (ILC)
Total528.22.6<0.0001
ERP528.82.6<0.0001
ERN527.21.3<0.0001
Medullary
Total524.0−0.7<0.0001
ERP574.4−0.30.4157
ERN523.9−1.1<0.0001
Inflammatory (IBC)
Total525.10.40.0469
ERP525.40.90.0081
ERN524.8−0.40.0805
Papillary
TotalNC3.8NANA
ERPNC4.0NANA
ERN623.90.40.5152
Mucinous
TotalNC4.4NANA
ERPNC4.5NANA
ERNNC3.1NANA
  • * All slope changes before and after the change-point are statistically significant (P value < 0.001).

  • The P values are for comparison of the slope after the change-point with zero; NC, no change; NA, not applicable.