Age- and Sex-adjusted associations between genotypes and colon cancer by family history of colorectal cancer
| Family History | No | Yes | ||
|---|---|---|---|---|
| IGF1 | ||||
| 192/192 (n) | 365/436 | 68/43 | ||
| 192/non-192 | 489/485 | 78/48 | ||
| Non-192 | 139/148 | 31/11 | ||
| 192/192 OR (95% CI) | 1.0 | 1.0 | ||
| 192/non-192 | 1.2 (1.0-1.5) | 1.0 (0.6-1.8) | ||
| Non-192 | 1.1 (0.9-1.5) | 1.8 (0.8-3.9) | ||
| IGFBP3 | ||||
| CC (n) | 251/319 | 52/21 | ||
| AC | 526/511 | 87/54 | ||
| AA | 215/234 | 38/24 | ||
| CC OR (95% CI) | 1.0 | 1.0 | ||
| AC | 1.3 (1.1-1.6) | 0.7 (0.4-1.2) | ||
| AA | 1.2 (0.9-1.5) | 0.6 (0.3-1.3) | ||
| IRS1 | ||||
| GG (n) | 854/948 | 144/83 | ||
| GR/RR | 154/116 | 29/19 | ||
| GG OR (95% CI) | 1.0 | 1.0 | ||
| GR/RR | 1.5 (1.1-1.9) | 0.8 (0.4-1.5) | ||
| IRS2 | ||||
| GG (n) | 396/442 | 71/39 | ||
| GD | 341/505 | 68/47 | ||
| DD | 108/119 | 20/15 | ||
| GG OR (95% CI) | 1.0 | 1.0 | ||
| GD | 0.7 (0.6-0.9) | 0.8 (0.5-1.3) | ||
| DD | 1.0 (0.8-1.4) | 0.8 (0.3-1.6) | ||