Table 4.

Age- and Sex-adjusted associations between genotypes and colon cancer by family history of colorectal cancer

Family HistoryNoYes
IGF1
    192/192 (n)365/43668/43
    192/non-192489/48578/48
    Non-192139/14831/11
    192/192 OR (95% CI)1.01.0
    192/non-1921.2 (1.0-1.5)1.0 (0.6-1.8)
    Non-1921.1 (0.9-1.5)1.8 (0.8-3.9)
IGFBP3
    CC (n)251/31952/21
    AC526/51187/54
    AA215/23438/24
    CC OR (95% CI)1.01.0
    AC1.3 (1.1-1.6)0.7 (0.4-1.2)
    AA1.2 (0.9-1.5)0.6 (0.3-1.3)
IRS1
    GG (n)854/948144/83
    GR/RR154/11629/19
    GG OR (95% CI)1.01.0
    GR/RR1.5 (1.1-1.9)0.8 (0.4-1.5)
IRS2
    GG (n)396/44271/39
    GD341/50568/47
    DD108/11920/15
    GG OR (95% CI)1.01.0
    GD0.7 (0.6-0.9)0.8 (0.5-1.3)
    DD1.0 (0.8-1.4)0.8 (0.3-1.6)