Table 3.

Joint effects of genetic polymorphisms on colon cancer risk

IGF1
P (Relative Excess Risk from Interaction, Wald χ2)
192/192192/Non-192Non-192
IGFBP3
    CC (n)122/130132/17143/370.64, 0.02
    AC216/230293/25490/78
    AA88/113122/10234/41
    CC OR (95% CI)1.00.8 (0.6-1.2)1.2 (0.7-2.1)
    AC1.0 (0.7-1.4)1.2 (0.9-1.7)1.2 (0.8-1.8)
    AA0.8 (0.6-1.2)1.3 (0.9-1.8)0.9 (0.5-1.5)
IRS1
    GG (n)372/422462/461138/1430.20, 0.34
    GR/RR56/5593/6528/14
    GG OR (95% CI)1.01.1 (0.9-1.4)1.1 (0.8-1.4)
    GR/RR1.2 (0.8-1.7)1.6 (1.1-2.3)2.3 (1.2-4.4)
IRS2
    GG (n)171/190223/21770/700.74, 0.90
    GD163/228190/25651/64
    DD44/5862/5521/21
    GG OR (95% CI)1.01.1 (0.9-1.5)1.1 (0.8-1.7)
    GD0.8 (0.6-0.11)0.8 (0.6-1.1)0.9 (0.6-1.4)
    DD0.8 (0.5-1.3)1.2 (0.8-1.9)1.1 (0.6-2.1)
IGFBP3
CCACAA
IRS1
    GG (n)250/296507/497211/2300.64, 0.92
    GR/RR48/4396/6635/25
    GG OR (95% CI)1.01.2 (1.0-1.5)1.1 (0.8-1.4)
    GR/RR1.3 (0.8-2.1)1.7 (1.2-2.5)1.7 (1.02-2.8)
IRS2
    GG (n)131/140236/22999/1070.85, 0.78
    GD111/167208/26384/118
    DD31/3161/6835/33
    GG OR (95% CI)1.01.1 (0.8-1.5)1.0 (0.7-1.4)
    GD0.7 (0.5-1.0)0.8 (0.6-1.1)0.8 (0.5-1.1)
    DD1.1 (0.6-1.8)1.0 (0.6-1.4)1.1 (0.7-1.9)
IRS2
GGGDDD
IRS1
    GG (n)392/425346/483111/1170.16, 0.22
    GR/RR71/5161/6514/17
    GG OR (95% CI)1.00.8 (0.6-0.9)1.0 (0.8-1.4)
    GR/RR1.5 (1.0-2.2)1.0 (0.7-1.5)0.9 (0.4-1.8)
  • NOTE: Adjusted for age and sex.