Table 2.

Age-adjusted associations between genotypes and colon and rectal cancer

Colon
Rectal
EveryoneMenWomenEveryoneMenWomen
IGF1
    192/192 (n)*433/479234/273199/206327/399194/228133/171
    192/non-192577/533331/297236/236348/450201/260147/190
    Non-192170/15988/7682/83102/13662/6840/68
    192/192 OR (95% CI)1.01.01.01.01.01.0
    192/non-1921.2 (1.0-1.4)1.3 (1.0-1.6)1.0 (0.8-1.4)1.0 (0.8-1.2)0.9 (0.7-1.2)1.0 (0.7-1.4)
    Non-1921.2 (0.9-1.5)1.4 (0.9-1.9)1.0 (0.7-1.5)0.9 (0.7-1.2)1.1 (0.7-1.6)0.7 (0.5-1.2)
IGFBP3
    CC (n)303/340153/176150/164221/267120/146101/121
    AC613/565355/320258/245384/517238/299146/218
    AA253/258143/143110/115144/20599/11475/91
    CC OR (95% CI)1.01.01.01.01.01.0
    AC1.2 (1.0-1.5)1.3 (1.0-1.7)1.2 (0.9-1.5)0.9 (0.7-1.1)1.0 (0.7-1.3)0.8 (0.6-1.1)
    AA1.1 (0.9-1.4)1.1 (0.8-1.6)1.0 (0.7-1.5)1.0 (0.8-1.4)1.1 (0.7-1.5)1.0 (0.7-1.5)
IRS1
    GG (n)998/1,031557/562441/469681/473397/496284/377
    GR/RR183/13599/8084/55100/11562/6438/51
    GG OR (95% CI)1.01.01.01.01.01.0
    GR/RR1.4 (1.1-1.9)1.3 (0.9-1.7)1.6 (1.1-2.3)1.1 (0.8-1.5)1.2 (0.8-1.7)1.0 (0.6-1.5)
IRS2
    GG (n)467/481264/267203/214325/421194/232131/189
    GD406/552234/303175/249343/423193/247150/176
    DD128/13479/7049/6498/13967/7931/60
    GG OR (95% CI)1.01.01.01.01.01.0
    GD0.8 (0.6-0.9)0.8 (0.6-1.0)0.7 (0.6-1.0)1.0 (0.9-1.3)0.9 (0.7-1.2)1.2 (0.9-1.7)
    DD1.0 (0.7-1.3)1.1 (0.8-1.6)0.8 (0.5-1.2)0.9 (0.7-1.2)1.0 (0.7-1.5)0.7 (0.4-1.2)
  • * n, cases/controls.