Table 3.

Vascular density of mammary carcinomas and pregnant mammary gland as categorized by blood vessel size

nDPCRegionTypeVessel Size Classification Scheme (μm2)
≤10>10 and ≤25>25 and ≤50>50 and ≤75>75Total
AC1835ETCount61.1 (28.3, 57.4)174.8 (132.6, 285.3)90.2 (63.9, 117.7)35.5 (25.5, 40.5)112.1 (99.4, 139.7)525.9 (382.2, 583.6)
Area475.6 (187.8, 657.3)2,867.8 (2,241.7, 4,652.9)3,098.9 (2,165.4, 4,069.6)2,154.7 (1,490.1, 2,527.6)51,557.0 (28,348.7,73,397.0)60,786.9 (40,166.1, 85,536.7)
AC1835ITCount9.1 (2.5, 18.6)28.0 (13.9, 56.1)11.0 (5.6, 17.9)3.5 (0.0, 7.9)6.8 (2.3, 11.9)60.5 (35.1, 103.1)
Area59.3 (21.8, 130.3)451.4 (207.3, 910.8)435.0 (180.3, 648.4)225.7 (0.0, 499.6)1,065.3 (192.3, 1,980.9)2,507.2 (1,548.7, 3,616.4)
AC1835TotalCount34.3 (11.9, 50.1)92.8 (65.8, 150.9)41.8 (34.5, 48.7)16.6 (12.9, 20.9)49.4 (40.2, 55.4)228.4 (162.4, 321.9)
Area263.6 (83.3, 368.8)154.4 (1,090.3, 2,437.0)1,461.7 (1,230.6, 1,673.2)1,025.5 (797.8, 1,287.5)18,988.6 (12,446.8, 31,712.4)23,485.0 (16,661.6, 37,347.7)
MPMG80ELCount36.9 (24.7, 56.1)330.5 (208.4, 381.7)84.4 (51.1, 138.1)0.0 (0.0, 16.4)7.23 (0.0, 28.3)502.5 (356.8, 564.7)
Area270.8 (206.3, 448.0)5,840.4 (3,728.0, 6,569.3)3,081.3 (1,670.3, 4,450.8)0.0 (0.0, 921.7)1,577.0 (0.0, 6,079.7)11,506.0 (10,376.1, 14,840.0)
MPMG80ILCount283.7 (203.4, 424.7)739.6 (603.7, 853.0)79.3 (69.3, 120.2)24.6 (11.2, 47.9)24.0 (0.0, 66.9)1,222.0 (1,037.7, 1,359.0)
Area2,040.5 (1,546.8, 3,229.5)11,142.4 (9,691.9, 13,325.2)3,183.4 (2,208.2, 3,987.1)1,406.2 (673.4, 3,105.7)2,493.2 (0.0, 19,035.5)28,268.6 (18,992.3, 35,295.0)
MPMG80TotalCount162.1 (112.0, 226.7)451.3 (407.6, 565.6)110.0 (60.1, 123.1)11.8 (9.5, 23.4)13.1 (0.0, 49.6)787.3 (656.5, 888.2)
Area1,218.9 (830.5, 1,713.9)7,330.6 (6,908.7, 8,919.9)3,501.8 (2,079.3, 4,221.3)686.3 (541.0, 1,478.1)1,776.5 (0.0, 13,551.7)17,543.4 (13,865.8, 24,359.2)
  • NOTE: DPC, days post carcinogen. For AC, blood vessel sizes were counted in a 50 μm wide band circumscribing each carcinoma, the extratumoral region (ET), and within each carcinoma, the intratumoral region (IT). For MPMG, blood vessels were counted in a 50 μm band circumscribing each lobule (EL), and within each lobule, intralobular region (IL). All values are expressed as medians (upper limit, lower limit of the interquartile range: the lower limit is the 25th percentile and the upper limit is the 75th percentile). Fifty percent of the data lie in the interquartile range, which is a stable measure of dispersion for small samples. A tabular presentation in which these data are expressed as means ± SEM or medians with 95% confidence intervals can be accessed at http://cpl.colostate.edu/angiogenesis. Count data are number of blood vessels per unit of assessed area (mm2) within the indicated vessel size criteria. Area data are blood vessel area (μm2) per unit of assessed area (mm2) within the indicated vessel size criteria. Total vascular density and vascular density in all vessel size categories were higher in mammary carcinomas than in DCIS (P < 0.001).