Table 2.

Vascular density of TEBs as categorized by blood vessel size

nMNUDPCTypeVessel size classification scheme (μm2)
≤10>10 and ≤25>25 and ≤50>50 and ≤75>75Total
93No0Count*,†0.0 (0.0, 0.0)0.0 (0.0, 0.0)27.5 (0.0, 38.0)0.0 (0.0, 31.5)0.0 (0.0, 35.4)56.5 (37.6, 91.1)
Area*,0.0 (0.0, 0.0)0.0 (0.0, 0.0)968.9 (0.0, 1,375.3)0.0 (0.0, 1,953.7)0.0 (0.0, 5,600.5)3,988.2 (2,015.8, 6,838.8)
34No28Count0.0 (0.0, 0.0)40.0 (0.0, 92.9)0.0 (0.0, 35.0)0.0 (0.0, 27.3)0.0 (0.0, 34.6)94.2 (62.7, 146.9)
Area0.0 (0.0, 0.0)700.9 (0.0, 1,188.0)0.0 (0.0, 985.0)0.0 (0.0, 1,715.0)0.0 (0.0, 5,177.4)2,635.2 (1,857.3, 9,676.9)
40Yes28Count0.0 (0.0, 13.3)24.2 (0.0, 45.3)13.2 (0.0, 37.4)0.0 (0.0, 0.0)0.0 (0.0, 23.4)71.3 (45.5, 93.5)
Area0.0 (0.0, 84.0)378.8 (0.0, 675.9)405.4 (0.0, 1,208.7)0.0 (0.0, 0.0)0.0 (0.0, 6,005.2)1,763.9 (784.4, 8,596.8)
75No35Count0.0 (0.0, 0.0)48.5 (29.8, 74.0)0.0 (0.0, 36.4)0.0 (0.0, 0.0)0.0 (0.0, 0.0)73.9 (50.3, 101.3)
Area0.0 (0.0, 0.0)785.8 (380.0, 1,209.0)0.0 (0.0, 1,206.5)0.0 (0.0, 0.0)0.0 (0.0, 0.0)1,744.6 (1,100.8, 2,843.1)
70Yes35Count0.0 (0.0, 28.2)32.1 (0.0, 61.2)0.0 (0.0, 0.0)0.0 (0.0, 0.0)0.0 (0.0, 29.0)72.2 (144.4, 114.6)
Area0.0 (0.0, 222.9)453.1 (0.0, 903.8)0.0 (0.0, 0.0)0.0 (0.0, 0.0)0.0 (0.0, 7,886.4)3,035.2 (1,199.0, 8,920.2)
  • NOTE: DPC, days post carcinogen.

  • * All values are expressed as medians (upper limit, lower limit of the interquartile range: the lower limit is the 25th percentile and the upper limit is the 75th percentile). Fifty percent of the data lie in the interquartile range, which is a stable measure of dispersion for small samples. A tabular presentation in which these data are expressed as means ± SEM or medians with 95% confidence intervals can be accessed at http://cpl.colostate.edu/angiogenesis.

  • Count data are number of blood vessels per unit of assessed area (mm2) within the indicated vessel size criteria.

  • Area data are blood vessel area (μm2) per unit of assessed area (mm2) within the indicated vessel size criteria.

  • § Statistical evaluation of these median data as described in Materials and Methods indicated that carcinogen treatment did not increase vascular density of TEBs measured as area (P = 0.13) or counts (P = 0.54) per unit of area assessed. Similar nonsignificant results were obtained with the zero inflated negative binomial analysis of the count data and the Tobit analysis of the area data.