Table 3.

Independent RRs*for incident colorectal cancer of glycated HbA1c and diabetes in 9,605 men and women ages 45 to 79 years, 1995 to 2002

Age and sex adjusted, RR (95% CI)PAge, sex, and risk factor Adjusted, RR (95% CI)P
All incident colorectal cancer (n = 67/9,605)
Model 1HbA1c (per 1% increase)1.33 (1.11-1.56)0.0011.34 (1.12-1.59)0.001
Model 2Diabetes history (yes vs. no)3.18 (1.36-7.40)0.0072.78 (1.10-7.00)0.03
Model 3HbA1c (per 1% increase)1.24 (0.99-1.55)0.051.30 (1.04-1.61)0.02
Diabetes history (yes vs. no)1.76 (0.60-5.18)0.301.35 (0.43-4.24)0.61
Colorectal cancer mortality only (n = 22/9,605)
Model 1HbA1c (per 1% increase)1.30 (0.95-1.78)0.101.32 (0.96-1.81)0.04
Model 2Diabetes history (yes vs. no)4.78 (1.39-16.44)0.013.60 (0.81-15.89)0.09
Model 3HbA1c (per 1% increase)1.07 (0.70-1.64)0.761.28 (0.85-1.92)0.25
Diabetes history (yes vs. no)4.04 (0.77-21.15)0.091.83 (0.26-12.81)0.52
Colorectal cancer nonfatal cases (n = 45/9,605)
Model 1HbA1c (per 1% increase)1.35 (1.10-1.66)0.0041.33 (1.08-1.64)0.007
Model 2Diabetes history (yes vs. no)2.33 (0.72-7.60)0.162.42 (0.72-7.74)0.15
Model 3HbA1c (per 1% increase)1.35 (1.06-1.73)0.021.33 (1.03-1.70)0.03
Diabetes history (yes vs. no)1.00 (0.24-4.12)0.991.07 (0.26-4.47)0.92
Excluding cases occurring within 2 years follow-up (n = 58/9,517)
Model 1HbA1c (per 1% increase)1.31 (1.08-1.58)0.0051.31 (1.08-1.59)0.006
Model 2Diabetes history (yes vs. no)3.77 (1.61-8.86)0.0023.32 (1.31-8.42)0.01
Model 3HbA1c (per 1% increase)1.17 (0.91-1.51)0.221.21 (0.95-1.56)0.13
Diabetes history (yes vs. no)2.48 (0.82-7.56)0.111.96 (0.60-6.45)0.27
Men only, all incident colorectal cancers (n = 36/4,445)
Model 1HbA1c (per 1% increase)1.38 (1.12-1.69)0.0021.41 (1.15-1.73)0.001
Model 2Diabetes history (yes vs. no)3.89 (1.50-10.10)0.0053.37 (1.17-9.72)0.02
Model 3HbA1c (per 1% increase)1.25 (0.95-1.66)0.111.35 (1.04-1.76)0.02
Diabetes history (yes vs. no)2.14 (0.61-7.51)0.231.45 (0.38-5.59)0.59
Women only, all incident colorectal cancers (n = 31/5,160)
Model 1HbA1c (per 1% increase)1.23 (0.89-1.69)0.221.20 (0.86-1.68)0.28
Model 2Diabetes history (yes vs. no)1.77 (0.24-13.01)0.571.71 (0.23-12.64)0.60
Model 3HbA1c (per 1% increase)1.23 (0.84-1.79)0.291.20 (0.81-1.78)0.26
Diabetes history (yes vs. no)0.97 (0.09-10.06)0.981.02 (0.10-10.60)0.98
  • * Based on Cox proportional hazards model.

  • Risk factors are BMI and cigarette smoking habit and sex for the sex combined analyses.