Table 2.

Incident colorectal cancer rates and RRs*adjusted for age and age, sex, smoking, and BMI by category of glycated HbA1c level and known diabetes status in 9,605 men and women ages 45 to 79 years without known cancer at baseline, 1995 to 2003

Level of glycated HbA1c (%)
Known diabetesP (Trend)
<5%5.0-5.9%6.0-6.9%≥7%
Men and women (n)2,6275,721899137221
Rate/100 (n of events)0.4 (10)0.6 (35)1.4 (13)2.2 (3)2.7 (6)<0.001
RR (95% CI), age and sex adjusted1 (reference)1.13 (0.56-2.30)1.93 (0.83-4.47)2.94 (0.80-10.85)4.02 (1.44-11.22)
RR (95% CI), age and risk factor adjusted1 (reference)1.07 (0.53-2.20)1.95 (0.84-4.56)2.85 (0.76-10.7)3.35 (1.12-10.00)
Men (n)1,1522,63443476149
Rate/100 (n of events)0.3 (4)0.7 (18)1.6 (7)2.6 (2)3.4 (5)<0.001
RR (95% CI), age adjusted1 (reference)1.64 (0.55-4.85)3.10 (0.90-10.73)4.94 (0.89-27.35)6.96 (1.84-26.34)
RR (95% CI), age and risk factor adjusted1 (reference)1.61 (0.54-4.82)3.40 (0.97-11.92)5.19 (0.92-29.38)6.02 (1.47-24.65)
Women (n)1,4753,0874656172
Rate/100 (n of events)0.4 (6)0.6 (17)1.3 (6)1.6 (1)1.4 (1)0.03
RR (95% CI), age adjusted1 (reference)0.77 (0.30-1.98)1.14 (0.36-3.68)1.58 (0.19-13.46)1.57 (0.19-13.14)
RR (95% CI), age and risk factor adjusted1 (reference)0.70 (0.27-1.82)1.08 (0.33-3.50)1.36 (0.15-12.04)1.38 (0.16-11.76)
  • * Based on Cox proportional hazards model.

  • Risk factors are BMI and cigarette smoking habit and sex for the sex combined analyses.