Table 4.

Distributions of Genotypes and Adjusted ORs among Cases and Controls Stratified by Cumulative Cigarette Dose

GenotypeNever Smokers
Light Smoker (≤21 Pack-Years)
Heavy Smokers (>21 Pack-Years)
Controls
Cases
OR (95% CI)Controls
Cases
OR (95% CI)Controls
Cases
OR (95% CI)
n%n%n%n%n%n%
CYP1A1
    *1/*118579.72477.41.0017382.82376.71.005688.914587.31.00
    *1/*2, *2/*24720.3722.61.28 (0.42-3.61)3617.2723.32.37 (0.72-7.47)711.12112.61.00 (0.36-3.00)
GSTM1
    *1/*1, *1/*O9942.71341.91.0010248.8930.01.002844.49356.01.00
    *O/*O13357.31858.10.86 (0.34-2.17)10751.22170.02.68 (1.00-7.94)§3555.67344.00.82 (0.42-1.63)
GSTT1
    *1/*1, *1/*O20086.22683.91.0017885.22376.71.005384.114989.81.00
    *O/*O3213.8516.11.37 (0.37-4.43)3114.8723.32.56 (0.71-8.79)1015.91710.20.36 (0.13-0.99)
NQO1
    *1/*116069.02167.71.0014669.92066.71.004774.610965.71.00
    *1/*2, *2/*27231.01032.31.24 (0.47-3.18)6330.11033.30.91 (0.31-2.47)1625.45734.31.23 (0.58-2.66)
  • 21 is the overall median pack-years among smokers.

  • Adjusted for age and gender.

  • § P = 0.06.

  • P = 0.04.