Adjusted ORs for Lung Cancer Overall and for the Main Histologic Subtypes in Relation to Genotypes in Ever Smokers
| Genotype | Controls | Lung Cancer Cases | Squamous Cell Carcinoma | Small Cell Carcinoma | Adenocarcinoma | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | % | n | % | OR† (95% CI) | n | % | OR† (95% CI) | n | % | OR† (95% CI) | n | % | OR† (95% CI) | |||||||||||||||
| CYP1A1 | ||||||||||||||||||||||||||||
| *1/*1 | 230 | 84.2 | 261 | 83.6 | 1.00 | 95 | 82.6 | 1.00 | 58 | 89.2 | 1.00 | 66 | 80.5 | 1.00 | ||||||||||||||
| *1/*2, *2/*2 | 43 | 15.8 | 51 | 16.4 | 1.34 (0.72-2.49) | 20 | 17.4 | 1.57 (0.67-3.63) | 7 | 10.8 | 0.79 (0.26-2.16) | 16 | 19.5 | 1.21 (0.51-2.79) | ||||||||||||||
| GSTM1 | ||||||||||||||||||||||||||||
| *1/*1, *1/*O | 131 | 48.0 | 147 | 47.1 | 1.00 | 57 | 49.6 | 1.00 | 26 | 40.0 | 1.00 | 39 | 47.6 | 1.00 | ||||||||||||||
| *O/*O | 142 | 52.0 | 165 | 52.9 | 1.22 (0.79-1.91) | 58 | 50.4 | 1.12 (0.61-2.05) | 39 | 60.0 | 2.72 (1.32-5.90)‡ | 43 | 52.4 | 1.21 (0.65-2.26) | ||||||||||||||
| GSTT1 | ||||||||||||||||||||||||||||
| *1/*1, *1/*O | 232 | 85.0 | 271 | 86.9 | 1.00 | 99 | 86.1 | 1.00 | 59 | 90.8 | 1.00 | 73 | 89.0 | 1.00 | ||||||||||||||
| *O/*O | 41 | 15.0 | 41 | 13.1 | 0.74 (0.38-1.43) | 16 | 13.9 | 0.67 (0.27-1.59) | 6 | 9.2 | 0.45 (0.13-1.34) | 9 | 11.0 | 0.49 (0.17-1.27) | ||||||||||||||
| NQO1 | ||||||||||||||||||||||||||||
| *1/*1 | 194 | 71.1 | 205 | 65.7 | 1.00 | 69 | 60.0 | 1.00 | 44 | 67.7 | 1.00 | 58 | 70.7 | 1.00 | ||||||||||||||
| *1/*2, *2/*2 | 79 | 28.9 | 107 | 34.3 | 1.16 (0.72-1.88) | 46 | 40.0 | 1.78 (0.95-3.34) | 21 | 32.3 | 0.97 (0.45-2.01) | 24 | 29.3 | 1.02 (0.51-2.02) | ||||||||||||||