Table 3.

Adjusted ORs for Lung Cancer Overall and for the Main Histologic Subtypes in Relation to Genotypes in Ever Smokers

GenotypeControls
Lung Cancer Cases
Squamous Cell Carcinoma
Small Cell Carcinoma
Adenocarcinoma
n%n%OR (95% CI)n%OR (95% CI)n%OR (95% CI)n%OR (95% CI)
CYP1A1
    *1/*123084.226183.61.009582.61.005889.21.006680.51.00
    *1/*2, *2/*24315.85116.41.34 (0.72-2.49)2017.41.57 (0.67-3.63)710.80.79 (0.26-2.16)1619.51.21 (0.51-2.79)
GSTM1
    *1/*1, *1/*O13148.014747.11.005749.61.002640.01.003947.61.00
    *O/*O14252.016552.91.22 (0.79-1.91)5850.41.12 (0.61-2.05)3960.02.72 (1.32-5.90)4352.41.21 (0.65-2.26)
GSTT1
    *1/*1, *1/*O23285.027186.91.009986.11.005990.81.007389.01.00
    *O/*O4115.04113.10.74 (0.38-1.43)1613.90.67 (0.27-1.59)69.20.45 (0.13-1.34)911.00.49 (0.17-1.27)
NQO1
    *1/*119471.120565.71.006960.01.004467.71.005870.71.00
    *1/*2, *2/*27928.910734.31.16 (0.72-1.88)4640.01.78 (0.95-3.34)2132.30.97 (0.45-2.01)2429.31.02 (0.51-2.02)
  • Adjusted for age and gender.

  • P = 0.008.