Table 2.

Adjusted ORs for Lung Cancer Overall and for the Main Histologic Subtypes in Relation to Genotypes

GenotypeControls
Lung Cancer Cases
Squamous Cell Carcinoma
Small Cell Carcinoma
Adenocarcinoma
n%n%OR (95% CI)n%OR (95% CI)n%OR (95% CI)n%OR (95% CI)
CYP1A1
    *1/*143782.444084.01.0013681.91.008886.31.0012184.01.00
    *1/*2A, *2A/*2A5610.65811.11.09 (0.62-1.92)1810.91.34 (0.61-2.89)109.81.04 (0.42-2.43)1711.80.79 (0.35-1.69)
    *1/*2B, *2A/*2B377.0264.91.20 (0.58-2.44)127.21.55 (0.59-3.94)43.90.70 (0.17-2.36)64.20.90 (0.28-2.43)
GSTM1
    *1/*1, *1/*O24045.323745.21.008551.21.004039.21.006243.11.00
    *O/*O29054.728754.81.02 (0.73-1.44)8148.80.81 (0.50-1.31)6260.81.61 (0.94-2.82)8256.91.07 (0.67-1.71)
GSTT1
    *1/*1, *1/*O45686.045687.01.0014285.51.009290.21.0012888.91.00
    *O/*O7414.06813.00.85 (0.51-1.40)2414.50.94 (0.47-1.86)109.80.57 (0.23-1.31)1611.10.61 (0.29-1.24)
NQO1
    *1/*136869.434565.81.0010764.51.006765.71.009868.01.00
    *1/*215328.916832.11.11 (0.76-1.60)5533.11.33 (0.79-2.23)3231.40.97 (0.54-1.73)4329.91.21 (0.72-2.01)
*2/*291.7112.11.41 (0.45-4.36)42.43.02 (0.60-12.4)32.91.80 (0.32-7.88)32.11.33 (0.24-5.73)
  • Adjusted for age and gender.

  • Includes one subject with genotype CYP1A1*1/*2C.