Table 2.

Statistical model: an example of the procedure, based on the genetic code, which is used to evaluate the number of ways that a specific codon can yield a missense mutation

Codon 1657: CTG → Leucine, strongly hydrophobic
Possible mutations:
TTG → Leucine, strongly hydrophobic
ATG → Methionine, strongly hydrophobic
GTG → Valine, strongly hydrophobic
CCG → Proline*, moderately hydrophilic
CAG → Glutamine*, strongly hydrophilic
CGG → Arginine*, strongly hydrophilic
CTT → Leucine, strongly hydrophobic
CTC → Leucine, strongly hydrophobic
CTA → Leucine, strongly hydrophobic
  • NOTE: There are five combinations that code for missense mutations (italics). Only three (*) out of these five perturb the property, “strongly hydrophobic.” Refer to Table 1 for the classification of amino acid hydrophobicity. This type of analysis was performed for each of the 214 codon positions in the BRCT domain of human BRCA-1.