Associations between XRCC genotypes and colorectal adenoma risk in the NHS and the HPFS
| Genotype | HPFS | NHS | HPFS + NHS | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases (%) | Controls (%) | OR (95% CI)* | Cases (%) | Controls (%) | OR (95% CI)* | Cases (%) | Controls (%) | OR (95% CI)† | ||||||||||
| N | 376 (34.2) | 725 (65.8) | 556 (50.0) | 557 (50.0) | 932 (42.1) | 1282 (57.9) | ||||||||||||
| XRCC2 R188H | ||||||||||||||||||
| Arg/Arg | 302 (85.3) | 582 (84.6) | 1.00 (ref.) | 450 (86.9) | 441 (84.5) | 1.00 (ref.) | 751 (86.2) | 1021 (84.5) | 1.00 (ref.) | |||||||||
| Arg/His + His/His | 52 (14.7) | 106 (15.4) | 0.96 (0.65-1.42) | 68 (13.1) | 81 (15.5) | 0.81 (0.56-1.18) | 120 (13.8) | 187 (15.5) | 0.88 (0.68-1.13) | |||||||||
| XRCC3 A>G 4541 | ||||||||||||||||||
| A/A | 229 (62.9) | 467 (65.8) | 1.00 (ref.) | 365 (66.6) | 342 (62.6) | 1.00 (ref.) | 593 (65.1) | 808 (64.4) | 1.00 (ref.) | |||||||||
| A/G | 119 (32.7) | 223 (31.4) | 1.06 (0.79-1.43) | 167 (30.5) | 180 (33.0) | 0.87 (0.66-1.16) | 286 (31.4) | 402 (32.1) | 0.98 (0.81-1.18) | |||||||||
| G/G | 16 (4.4) | 20 (2.8) | 1.73 (0.84-3.56) | 16 (2.9) | 24 (4.4) | 0.65 (0.31-1.34) | 32 (3.5) | 44 (3.5) | 0.97 (0.61-1.57) | |||||||||
| XRCC3 A>G 17893 | ||||||||||||||||||
| A/A | 180 (49.2) | 329 (46.7) | 1.00 (ref.) | 256 (48.7) | 250 (47.5) | 1.00 (ref.) | 436 (48.9) | 578 (47.0) | 1.00 (ref.) | |||||||||
| A/G | 155 (42.4) | 303 (43.0) | 0.89 (0.66-1.20) | 212 (40.3) | 222 (42.2) | 0.87 (0.65-1.17) | 366 (41.1) | 524 (42.6) | 0.93 (0.77-1.12) | |||||||||
| G/G | 31 (8.5) | 73 (10.4) | 0.87 (0.52-1.48) | 58 (11.0) | 54 (10.3) | 1.00 (0.65-1.54) | 89 (10.0) | 127 (10.4) | 0.90 (0.67-1.22) | |||||||||
| XRCC3 T241M | ||||||||||||||||||
| Thr/Thr | 140 (39.6) | 257 (37.4) | 1.00 (ref.) | 191 (39.6) | 187 (39.4) | 1.00 (ref.) | 331 (39.6) | 442 (38.1) | 1.00 (ref.) | |||||||||
| Thr/Met | 164 (46.3) | 322 (46.8) | 0.90 (0.66-1.22) | 222 (46.1) | 218 (45.9) | 1.11 (0.82-1.52) | 385 (46.1) | 540 (46.5) | 0.95 (0.78-1.16) | |||||||||
| Met/Met | 50 (14.1) | 109 (15.8) | 0.87 (0.57-1.33) | 69 (14.3) | 70 (14.8) | 1.03 (0.66-1.63) | 119 (14.3) | 179 (15.4) | 0.89 (0.68-1.17) | |||||||||
Abbreviations: OR, odds ratio; CI, confidence interval.
↵* Conditional logistic regression adjusted for matching factors and family history of colorectal cancer, pack-years smoking, aspirin use, body mass index, postmenopausal hormone use (NHS), and intake of folic acid and alcohol.
↵† Unconditional logistic regression adjusted for age, sex, and family history of colorectal cancer.