Table 1.

Associations between MTHFR 677 C→T and 1298 A→C genotypes and endometrial cancer risk

Cases n (%)*Controls n (%)*OR (95% CI)
MTHFR 677 C→T (Ala→Val)Ala/Ala97 (44.5)299 (45.1)1.00 (reference)
Ala/Val99 (45.4)296 (44.6)1.10 (0.75-1.60)
Val/Val22 (10.1)68 (10.3)1.11 (0.62-1.99)
MTHFR 1298 A→C (Glu→Ala)Glu/Glu102 (46.6)302 (45.4)1.00 (reference)
Ala/Glu88 (40.2)285 (42.9)0.85 (0.59-1.22)
Ala/Ala29 (13.2)78 (11.7)0.88 (0.51-1.52)
  • * Numbers do not add to 222 cases and 666 controls due to missing genotypes.

  • ORs and 95% CIs calculated using conditional logistic regression accounting for the matching factors and additionally adjusted for body mass index prior to diagnosis, weight gain since age 18, age at menarche, ages at first birth and last birth, age at menopause, parity, pack-years of smoking, and first-degree family history of endometrial cancer or colon cancer.