Table 2.

OR and 95% CI of main effects of genetic polymorphisms from conventional analyses and hierarchical modeling

GeneAllele at riskCase no.Control no.Conventional (a)
Conventional (b)
Hierarchical (1)
Hierarchical (2)
Hierarchical (3)
Hierarchical (4)
Hierarchical (5)
Hierarchical (6)
OR (95% CI)OR (95% CI)OR (95% CI)OR (95% CI)OR (95% CI)OR (95% CI)OR (95% CI)OR (95% CI)
GSTM1null1321121.74 (1.17-2.58)1.61 (1.06-2.45)1.43 (1.02-1.99)1.49 (1.05-2.13)1.51 (1.06-2.14)1.51 (1.05-2.16)1.47 (1.06-2.03)1.57 (1.06-2.33)
GSTT1null43331.52 (0.92-2.51)1.57 (0.92-2.68)1.35 (0.92-1.99)1.43 (0.94-2.17)1.45 (0.96-2.20)1.44 (0.94-2.20)1.39 (0.96-2.02)1.50 (0.92-2.46)
GSTP1 105-114allele with both variants21240.92 (0.49-1.71)1.04 (0.54-2.01)1.13 (0.74-1.70)1.16 (0.72-1.86)1.20 (0.75-1.94)1.18 (0.72-1.92)1.19 (0.79-1.79)1.07 (0.60-1.92)
NAT2slow1231111.48 (1.00-2.19)1.28 (0.82-1.97)1.29 (0.93-1.77)1.30 (0.92-1.85)1.33 (0.93-1.90)1.31 (0.92-1.88)1.31 (0.94-1.81)1.29 (0.85-1.94)
NAT1fast80970.79 (0.53-1.17)0.92 (0.59-1.43)1.02 (0.73-1.43)0.90 (0.62-1.32)0.94 (0.66-1.36)0.91 (0.64-1.31)0.90 (0.63-1.29)0.91 (0.60-1.39)
SULT1A1Arg/Arg1211161.29 (0.87-1.91)1.27 (0.84-1.91)1.24 (0.90-1.69)1.24 (0.86-1.80)1.15 (0.80-1.66)1.14 (0.79-1.65)1.24 (0.87-1.77)1.26 (0.85-1.88)
CYP1B1Val/Val31360.90 (0.53-1.52)0.95 (0.55-1.66)1.08 (0.74-1.60)1.05 (0.67-1.65)0.98 (0.64-1.51)1.20 (0.72-1.99)1.08 (0.72-1.62)1.01 (0.60-1.68)
MPOG/G, G/A1941923.17 (1.32-7.59)3.02 (1.21-7.53)1.58 (0.87-2.88)1.64 (0.81-3.34)1.80 (0.94-3.45)1.97 (0.99-3.92)1.41 (0.86-2.31)2.19 (1.03-4.69)
COMTVal/Met, Met/Met1391570.80 (0.52-1.23)0.86 (0.55-1.36)1.01 (0.71-1.44)1.00 (0.66-1.52)1.07 (0.70-1.64)0.98 (0.66-1.46)1.04 (0.72-1.51)0.91 (0.59-1.40)
MnSODVal/Val68451.91 (1.23-2.96)1.69 (1.06-2.70)1.47 (1.02-2.10)1.54 (1.02-2.32)1.58 (1.07-2.33)1.51 (1.00-2.26)1.50 (1.03-2.20)1.67 (1.07-2.60)
NQO1Pro/Ser, Ser/Ser88791.33 (0.89-1.97)1.36 (0.90-2.06)1.28 (0.93-1.77)1.41 (0.98-2.03)1.36 (0.96-1.93)1.30 (0.89-1.90)1.42 (1.00-2.01)1.38 (0.93-2.06)
XRCC1Arg/Gln, Gln/Gln1081220.87 (0.59-1.28)0.90 (0.59-1.35)1.02 (0.73-1.42)0.96 (0.66-1.38)0.97 (0.67-1.40)0.96 (0.66-1.39)0.97 (0.69-1.38)0.91 (0.61-1.36)
XRCC3Thr/Thr89711.60 (1.07-2.38)1.68 (1.10-2.55)1.43 (1.01-2.02)1.41 (0.94-2.12)1.39 (0.93-2.09)1.43 (0.95-2.14)1.35 (0.95-1.92)1.59 (1.06-2.37)
XPDLys/Gln, Gln/Gln1221340.92 (0.62-1.37)1.04 (0.68-1.59)1.08 (0.79-1.49)1.03 (0.71-1.49)1.04 (0.72,1.50)1.03 (0.71-1.50)1.03 (0.72-1.47)1.03 (0.68-1.55)
Estimated τ20.0380.050.040.05
  • NOTE: (a) Model parameters of interest included one at a time; (b) all parameters included in one model. (1) No prior Z matrix and no prior τ2; (2) basic Z matrix and no prior τ2; (3) Z matrix variant 1 and no prior τ2; (4) Z-matrix variant 2 and no prior τ2; (5) basic Z matrix and prior τ2 = 0.05; (6) basic Z matrix and prior τ2 = 0.35.

    Abbreviation: OR, odds ratio adjusted for age.