Table 1.

Z matrices used in the hierarchical model

GeneSingle nucleotide polymorphismHigh-risk genotypeBasic Z matrix
Z-matrix variant 1
Z-matrix variant 2
Reduced detoxificationEnhanced activationIncreased oxidative stressDecreased DNA repairReduced detoxificationEnhanced activationIncreased oxidative stressDecreased DNA repairReduced detoxificationEnhanced activationIncreased oxidative stressDecreased DNA repair
GSTM1null100010001000
GSTT1null100010001000
GSTP1*Ile105Val Ala114val≥one allele*C100010001000
NAT2*5A, *6A, *7ASlow100010001000
NAT1*10 and *11Fast01000100−1100
SULT1A1Arg213HisArg/Arg11001100−1100
CYP1B1Val432LeuVal/Val011001000110
MPOG-463AG/G, G/A011001100110
COMTVal108MetVal/Met, Met/Met001001100010
MnSODAla-9ValVal/Val001001100010
NQO1Pro187SerPro/Ser, Ser/Ser111001101−110
XRCC1Arg399GlnArg/Gln, Gln/Gln000100010001
XRCC3Thr241MetThr/Thr000100010001
XPDLys751GlnLys/Gln, Gln/Gln000100010001
  • * GSTP1 allele which has both 105Val and 114Val.

  • *5A: T341C, C481T; *6A: C282T, G590A; *7A: G857A; Slow: at least two slow acetylator alleles.

  • *10: T1088A, C1095A; *11: C-344T, A-40T, G445A, G459A, T640G, ▵9 between nt 1095 and 1090, C1095A; Fast: *10 or *11 homo-heterozygous.