Table 5.

Associations of breast cancer risk with join distributions of CYP11Agenotypes and selected surrogate measures of endogenous sex hormone exposure, the Shanghai Breast Cancer Study

Stratified variables (by median)Presence of the 8 (TAAAA) repeat allele
P value for trend test
No
One copy
Two copies
Cases/ControlsOR (95% CI)Cases/ControlsOR (95% CI)*Cases/ControlsOR (95% CI)
Years of menstruation
    <27295/4381.0 (reference)87/861.5 (1.1–2.1)5/51.5 (0.4–5.2)0.024
    ≥27480/4671.8 (1.4–2.3)128/792.8 (2.0–4.1)15/38.9 (2.5–31.4)<0.001
P for interaction = 0.381
Body mass index
    <22.75344/4481.0 (reference)101/901.5 (1.1–2.1)7/33.3 (0.8–13.0)0.004
    ≥22.75436/4591.3 (1.0–1.6)114/771.9 (1.4–2.7)13/53.4 (1.2–9.7)0.002
P for interaction = 0.964
Waist-to-hip ratio
    <0.798351/4631.0 (reference)93/831.5 (1.1–2.0)10/27.3 (1.6/33.5)<0.001
    ≥0.798429/4441.3 (1.1–1.6)122/542.0 (1.4–2.7)10/62.2 (0.8–6.0)0.007
P for interaction = 0.251
  • * Adjusted for age and education.

  • Reference group.