Table 1.

Total alcohol intake and risk of ovarian cancer by tumor type

Alcohol (standard drinks)aCases(%)Controls (n = 786; %)Adjusted ORb95% CITest for trendExcluding nondrinkers
All cancers (n = 696)
    None32.823.81.0
    <1/wk31.031.60.790.59–1.05
    1–6/wk22.729.10.660.48–0.90
    1–1.9/day8.27.90.780.50–1.23
    ≥2/day5.37.60.490.30–0.81P = 0.003P = 0.07
Invasive cancers (n = 570)
    None32.623.81.0
    <1/wk30.731.60.840.62–1.14
    1–6/wk23.529.10.730.53–1.02
    1–1.9/day8.47.90.850.53–1.36
    ≥2/day4.77.60.460.27–0.79P = 0.009P = 0.05
Borderline cancers (n = 126)
    None33.323.81.0
    <1/wk32.531.60.680.40–1.15
    1–6/wk19.129.10.470.26–0.85
    1–1.9/day7.17.90.660.27–1.58
    ≥2/day7.97.60.700.30–1.61P = 0.12P = 0.9
Serous cancers (n = 360)
    None32.523.81.0
    <1/wk32.531.60.900.64–1.27
    1–6/wk21.429.10.720.49–1.05
    1–1.9/day8.17.90.880.51–1.51
    ≥2/day5.67.60.610.35–1.17P = 0.09P = 0.3
Endometrioid and clear cell cancers (n = 147)
    None32.023.81.0
    <1/wk31.331.60.920.55–1.52
    1–6/wk23.129.10.850.49–1.47
    1–1.9/day8.87.91.340.62–2.88
    ≥2/day4.87.60.520.20–1.33P = 0.4P = 0.5
Mucinous cancers (n = 105)
    None28.623.81.0
    <1/wk36.231.60.850.49–1.50
    1–6/wk21.929.10.560.30–1.06
    1–1.9/day7.67.90.570.22–1.45
    ≥2/day5.77.60.440.16–1.20P = 0.03P = 0.07
Other histological types (n = 84)
    None40.223.81.0
    <1/wk18.331.60.340.17–0.68
    1–6/wk28.129.10.670.36–1.24
    1–1.9/day8.57.90.650.25–1.67
    ≥2/day4.97.60.370.12–1.18P = 0.15P = 0.5
  • a Assuming 12.5g of alcohol = 1 standard drink.

  • b OR adjusted for age (in years), age squared, level of education, BMI, smoking status (never, past, or current), duration of OC use, parity, and caffeine intake (quintiles).