Table 5.

Analysis of joint effects for XRCC1-R399Q and XRCC3-T241M genotypes on breast cancer risk

GenotypeCases (n = 402) n (%)Controls (n = 402) n (%)PaOR (95% CI)Multivariate adjusted OR (95% CI)b
XRCC1-R399QXRCC3-T241M
R/R + R/QT/T + T/M282 (70.2)303 (75.4)0.121.001.00
R/R + R/QM/M65 (16.2)42 (10.5)1.66 (1.09–2.53)1.66 (1.08–2.54)
Q/QT/T + T/M43 (10.7)43 (10.7)1.07 (0.68–1.69)1.03 (0.65–1.64)
Q/QM/M12 (3.0)14 (3.5)0.92 (0.42–2.03)0.92 (0.42–2.05)
  • a χ2 test for homogeneity of proportions in contingency table.

  • b Adjusted for ethnicity (Caucasian or Caucasian and other ethnic group), age (years), and FH of breast cancer (at least one first-degree relative).