Table 4.

Effects of genotypes and environmental exposures on breast cancer risk

ExposureaXRCC1-R399Q
XRCC3-T241M
GenotypeCases n (%)Controls n (%)Multivariate adjusted ORbGenotypeCases n (%)Controls n (%)Multivariate adjusted ORb
Adolescent smoking
    NoR/R + R/Q163 (48.1)180 (44.9)1.00T/T + T/M155 (45.7)184 (45.9)1.00
Q/Q25 (7.4)29 (7.2)0.89 (0.50–1.60)M/M33 (9.7)25 (6.2)1.50 (0.85–2.65)
    YesR/R + R/Q132 (38.9)165 (41.2)0.88 (0.64–1.21)T/T + T/M119 (35.1)161 (40.2)0.87 (0.63–1.20)
Q/Q19 (5.6)27 (6.7)0.76 (0.41–1.44)M/M32 (9.4)31 (7.7)1.24 (0.72–2.13)
Alcohol consumption
    NoR/R + R/Q137 (40.1)178 (44.3)1.00T/T + T/M125 (35.6)168 (41.8)1.00
Q/Q19 (5.6)24 (6.0)1.04 (0.54–1.99)M/M31 (9.1)34 (8.5)1.21 (0.70–2.09)
    YesR/R + R/Q160 (46.8)167 (41.5)1.24 (0.90–1.70)T/T + T/M151 (44.2)178 (44.3)1.12 (0.81–1.54)
Q/Q26 (7.6)33 (8.2)0.93 (0.53–1.66)M/M35 (10.2)22 (5.5)2.09 (1.16–3.78)
BMI
    NormalR/R + R/Q152 (60.8)151 (50.2)1.00T/T + T/M138 (55.2)156 (51.8)1.00
Q/Q26 (10.4)23 (7.6)1.03 (0.56–1.93)M/M40 (16.0)18 (6.0)2.68 (1.45–4.94)
    Overweight/obeseR/R + R/Q65 (26.0)110 (26.0)0.54 (0.36–0.79)T/T + T/M61 (24.4)113 (37.5)0.59 (0.39–0.87)
Q/Q7 (2.8)17 (5.7)0.40 (0.16–1.01)M/M11 (4.4)14 (4.7)0.75 (0.32–1.77)
Adolescent IR exposure
    NoR/R + R/Q181 (70.7)232 (68.8)1.00T/T + T/M164 (64.1)242 (71.8)1.00
Q/Q22 (8.6)44 (13.1)0.63 (0.36–1.10)M/M39 (15.2)34 (10.1)1.67 (1.00–2.78)
    YesR/R + R/Q41 (16.0)55 (16.3)0.97 (0.61–1.53)T/T + T/M40 (15.6)51 (15.1)1.16 (0.73–1.85)
Q/Q12 (4.7)6 (1.8)2.56 (0.93–7.03)M/M13 (5.1)10 (3.0)2.02 (0.86–4.76)
  • a Definition of variables: smoking (at least 1 cigarette/day for a 3-month period) under age 20; alcohol consumption (at least 1 beer/glass of wine/liquor once a week for at least a 6-month period); BMI (normal: 18.5–25 kg/m2, overweight/obese: >25 kg/m2); FH of breast cancer (at least one first-degree relative with breast cancer); and IR exposure (X-rays to the breast area) under age 20.

  • b Adjusted for ethnicity (Caucasian or Caucasian and other ethnic group), age (years), and FH of breast cancer (at least one first-degree relative).