Table 4.

Joint associationsabetween recent alcohol consumption and other risk factors for postmenopausal breast cancer in the CTS

Alcohol consumption
Nondrinkers<20 g/day≥20 g/day
Family history of breast cancer in a first degree relative
    No1.01.04 (0.89–1.22)1.44 (1.14–1.81)
    Yes1.63 (1.24–2.15)1.56 (1.24–1.96)1.44 (0.89–2.33)
BMI (kg/m2)
    <27.31.01.10 (0.93–1.31)1.41 (1.10–1.80)
    ≥27.3 1.21 (0.96–1.53)1.06 (0.85–1.32)1.33 (0.87–2.04)
Parous1.01.10 (0.94–1.29)1.40 (1.10–1.78)
Nulliparous1.26 (0.97–1.64)0.99 (0.78–1.25)1.31 (0.89–1.94)
Physically activeb
    Yes1.01.09 (0.91–1.31)1.32 (1.01–1.72)
    No1.12 (0.89–1.40)1.05 (0.85–1.30)1.53 (1.09–2.15)
Biopsy-diagnosed BBD
    No1.01.00 (0.85–1.19)1.26 (0.98–1.63)
    Yes1.35 (1.05–1.73)1.46 (1.19–1.79)1.97 (1.39–2.79)
Use of HRT
    Never1.01.00 (0.72–1.37)0.94 (0.54–1.65)
    Estrogen only1.18 (0.87–1.60)1.17 (0.88–1.56)1.54 (1.04–2.30)
    Estrogen plus progestin1.53 (1.14–2.05)1.63 (1.25–2.14)2.24 (1.59–3.14)
  • a RR (95% CI) adjusted for age, race/ethnicity, caloric intake, age at menarche, and except in models with these factors as main effects, for a family history of breast cancer, BMI, nulliparity/age at FFTP, physical activity, and duration of ERT use.

  • b Defined as 1.5 or more hours per week of strenuous or moderate exercise during the past 3 years.