Table 2.

Breast cancer risk by plasma folate levels and XRCC2 Arg188His

1 (Lowest)234 (Highest)P for trend
188His non-carriers
Cases/Controlsa170/155149/147136/145126/146
Multivariate ORb1.000.91 (0.66–1.25)0.84 (0.61–1.16)0.78 (0.56–1.08)0.18
Multivariate ORc1.000.98 (0.70–1.36)0.80 (0.57–1.12)0.74 (0.52–1.05)0.09
188His carriers
Cases/Controlsa35/1528/2524/2420/23
Multivariate ORb2.15 (1.13–4.10)1.00 (0.55–1.79)0.89 (0.49–1.64)0.77 (0.41–1.47)0.01
Multivariate ORc2.04 (1.05–3.97)1.00 (0.54–1.84)0.84 (0.45–1.59)0.77 (0.39–1.50)0.004
  • P, interaction = 0.31 in the multivariate model C

  • a The number of participants does not sum to total women because of missing data on genotype.

  • b Unconditional logistic regression adjusted for the matching variables: age, menopausal status, postmenopausal hormone use, date of blood draw, time of blood draw, and fasting status.

  • c Unconditional logistic regression adjusted for the matching variables, BMI at age 18 (continuous), weight gain since age 18 (<5 kg, 5–19.9, ≥20), age at menarche (<12 years, 12, 13, >13), age at menopause (<45, ≥45 to <50, ≥50 to <55 or ≥55 years), parity/age at first birth (nulliparous, 1–2 children/age at first birth ≤24 years, 1–2 children/age at first birth >24, 3+ children/age at first birth ≤24, 3+ children/age at first birth >24), first degree family history of breast cancer (yes/no), history of benign breast disease (yes/no), alcohol intake (0, >0 to <5, ≥5 to <15, ≥15 to <30, ≥30 g/day), and postmenopausal hormone use (never use, past use, current use <5years, current use ≥5 years).