Table 1.

Frequency of IGF-I and IGFBP-3 variants, and ORs and 95% CIs for their association with CaP in sibling-based study

Gene variantCases (%)Controls (%)OR (95% CI)a
IGF-I (CA)n repeatsb
≤1730 (3.4)38 (4.0)
18c65 (7.4)67 (7.0)0.97 (0.67–1.41)
19548 (62.3)586 (61.2)1.0 (referent)
20d170 (19.3)180 (18.8)0.99 (0.78–1.27)
≥2167 (7.7)87 (9.1)
IGFBP-3 (−202)
CC126 (28.6)115 (29.0)1.0 (referent)
AC217 (49.3)225 (47.0)0.81 (0.51–1.30)
AA97 (22.1)139 (24.0)0.76 (0.40–1.44)
  • a Adjusted for age.

  • b Allele counts from chromosomes (twice the total sample size).

  • c OR and 95% CI for ≤18 repeats.

  • d OR and 95% CI for ≥20 repeats.