Recent hormone replacement therapy | MTHFR 677 | MTHFR 1298 | ||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AA | AC | CC | ||||||||||||||||||||||
Cases (n) | Ctrls (n) | Odds ratio | 95% confidence interval | Cases (n) | Ctrls (n) | Odds ratio | 95% confidence interval | Cases (n) | Ctrls (n) | Odds ratio | 95% confidence interval | |||||||||||||
No | CC | 70 | 61 | 1.0 | — | 107 | 120 | 0.8 | (0.5–1.2) | 35 | 76 | 0.4 | (0.2–0.7) | |||||||||||
CT | 115 | 127 | 0.8 | (0.5–1.2) | 92 | 100 | 0.8 | (0.5–1.3) | ||||||||||||||||
TT | 46 | 64 | 0.6 | (0.4–1.1) | ||||||||||||||||||||
Yes | CC | 10 | 31 | 0.3 | (0.1–0.6) | 41 | 61 | 0.6 | (0.3–1.0) | 12 | 23 | 0.5 | (0.2–1.1) | |||||||||||
CT | 33 | 58 | 0.5 | (0.3–0.9) | 31 | 43 | 0.6 | (0.4–1.1) | ||||||||||||||||
TT | 17 | 26 | 0.6 | (0.3–1.2) |
^{a} Adjusted for age, body mass index, lifetime vigorous activity, energy intake, diet fiber, calcium, usual number of cigarettes smoked. Relative excess risk due to interaction P < 0.01. Wald χ^{2} test of slopes, A1298C/HRT use relationship P = 0.04. Wald χ^{2} test of slopes, C677T/HRT use relationship P = 0.09.