Table 4

Association between MTHFR genotypes and colon cancer risk, stratified by hormone replacement therapy (postmenopausal women)a

Recent hormone replacement therapyMTHFR 677MTHFR 1298
AAACCC
Cases (n)Ctrls (n)Odds ratio95% confidence intervalCases (n)Ctrls (n)Odds ratio95% confidence intervalCases (n)Ctrls (n)Odds ratio95% confidence interval
NoCC70611.01071200.8(0.5–1.2)35760.4(0.2–0.7)
CT1151270.8(0.5–1.2)921000.8(0.5–1.3)
TT46640.6(0.4–1.1)
YesCC10310.3(0.1–0.6)41610.6(0.3–1.0)12230.5(0.2–1.1)
CT33580.5(0.3–0.9)31430.6(0.4–1.1)
TT17260.6(0.3–1.2)
  • a Adjusted for age, body mass index, lifetime vigorous activity, energy intake, diet fiber, calcium, usual number of cigarettes smoked. Relative excess risk due to interaction P < 0.01. Wald χ2 test of slopes, A1298C/HRT use relationship P = 0.04. Wald χ2 test of slopes, C677T/HRT use relationship P = 0.09.