Table 3A

Continued

MTHFR 677MTHFR 1298 AAACCC
Cases (n)Controls (n)ORc95% CICases (n)Controls (n)OR95% CICases (n)Controls (n)OR95% CI
Long-term alcohol intakef - P interaction = 0.62
  CC
   None33341.051670.8(0.4–1.5)25320.8(0.4–1.6)
   Mod15210.7(0.3–1.6)39420.9(0.5–1.7)9200.4(0.2–1.0)
   High881.1(0.3–3.2)18161.1(0.5–2.6)2120.2(0.0–0.8)
  CT
   None49580.8(0.4–1.5)64620.7(0.4–1.4)
   Mod36600.6(0.3–1.2)50420.9(0.4–1.7)
   High21181.2(0.5–2.7)20120.6(0.2–1.8)
  TT
   None26370.7(0.4–1.5)
   Mod15210.8(0.3–1.8)
   High390.3(0.1–1.3)
  • a Adjusted for age, body mass index, lifetime vigorous activity, energy intake, dietary fiber, calcium, usual number of cigarettes and folate, vitamin B2, vitamin B6, vitamin B12, methionine, and alcohol, where appropriate.

  • b MTHFR 677/1298 genotypes CT/CC, TT/AC, and TT/CC were not observed in the study population.

  • c OR, odds ratio; CI, confidence interval.

  • d Tertile cut-off points for men were: folate, 318/459 mcg/day; vitamin B12, 4.8/7.8 mcg/day. Tertile cut-off points for women were: folate, 273/388 mcg/day; vitamin B12, 3.5, 5.7 mcg/day.

  • e Relative excess risk due to interaction (31).

  • f High alcohol intake from consumption of beer, wine, and liquor averaged for 10 and 20 years ago: men, ≥20 gm/day; women, ≥10 gm/day.