Table 3

Associations between MTHFR genotypes and colon cancer risk, stratified by dietary nutrient intakes (nonsupplement users)a,b

MTHFR 677MTHFR 1298 AAACCC
Cases (n)Controls (n)ORc95% CICases (n)Controls (n)OR95% CICases (n)Controls (n)OR95% CI
Men
 Folated P interaction = 0.90e
  CC
   Low32331.038500.8(0.4–1.6)20231.0(0.4–2.1)
   Int35301.3(0.6–2.5)53551.0(0.5–1.9)27211.3(0.6–2.9)
   High28390.7(0.3–1.5)37530.6(0.3–1.3)24261.0(0.4–2.3)
  CT
   Low54541.1(0.6–2.1)45481.1(0.6–2.0)
   Int56640.9(0.5–1.7)51561.0(0.5–1.9)
   High37530.7(0.3–1.4)52511.1(0.5–2.2)
  TT
   Low18230.8(0.4–1.9)
   Int18360.6(0.3–1.2)
   High20260.8(0.4–1.8)
 Vitamin B12dP interaction = 0.90e
  CC
   Low25331.032610.7(0.4–1.4)19191.5(0.6–3.4)
   Int33371.3(0.6–2.6)54441.7(0.9–3.3)29311.4(0.7–2.9)
   High37321.6(0.7–3.4)42531.0(0.5–2.2)23201.4(0.6–3.4)
  CT
   Low35511.0(0.5–2.1)41441.4(0.7–2.8)
   Int55541.4(0.7–2.7)59621.4(0.7–2.7)
   High57661.1(0.6–2.2)48491.3(0.8–2.7)
  TT
   Low16270.9(0.5–1.9)
   Int19340.8(0.4–1.8)
   High21241.1(0.5–2.6)
 Long-term alcohol intakef P interaction = 0.03e
  CC
   None31251.028400.5(0.3–1.1)14210.5(0.2–1.3)
   Mod31440.6(0.3–1.1)59670.6(0.3–1.2)32300.8(0.4–1.7)
   High33330.6(0.3–1.3)41510.5(0.3–1.0)25190.8(0.4–1.9)
  CT
   None38410.8(0.4–1.5)38480.7(0.3–1.3)
   Mod63700.7(0.4–1.3)64740.7(0.3–1.2)
   High46600.5(0.2–0.9)46330.9(0.4–1.9)
  TT
   None21260.6(0.3–1.4)
   Mod17430.3(0.1–0.7)
   High18160.7(0.3–1.8)
Women
 FolatedP interaction = 0.09e
  CC
   Low21141.035460.5(0.2–1.1)16180.6(0.2–1.7)
   Int19290.5(0.2–0.8)36420.6(0.3–1.4)12260.3(0.2–0.8)
   High16200.5(0.2–1.3)37370.7(0.3–1.7)8200.2(0.1–0.7)
  CT
   Low44580.5(0.3–1.1)28370.5(0.2–1.2)
   Int28430.4(0.2–0.9)28420.5(0.2–1.1)
   High34350.7(0.3–1.1)26370.5(0.2–1.4)
  TT
   Low16270.4(0.2–0.9)
   Int13170.5(0.3–1.3)
   High15230.4(0.2–1.0)
 Vitamin B12dP interaction = 0.90e
  CC
   Low22191.037450.7(0.3–1.6)14170.8(0.3–2.1)
   Int16250.6(0.2–1.4)27500.4(0.2–1.0)15250.4(0.2–1.1)
   High18190.7(0.3–1.3)44301.2(0.5–2.8)7220.2(0.1–0.7)
  CT
   Low32440.6(0.3–1.4)28410.6(0.3–1.3)
   Int40410.8(0.4–1.8)30370.7(0.3–1.6)
   High34510.5(0.2–1.2)24380.6(0.2–1.4)
  TT
   Low19260.7(0.3–1.5)
   Int11250.4(0.1–1.0)
   High14160.7(0.3–2.1)