Table 2

Association between MTHFR genotype and colon cancer risk stratified by sex and agea,b

MTHFR 677AAMTHFR 1298 ACCC
Cases (n)Controls (n)ORc95% CICases (n)Controls (n)OR95% CICases (n)Controls (n)OR95% CI
Men
  CC1311451.01782170.9(0.6–1.2)931031.0(0.7–1.4)
  CT2112361.0(0.7–1.3)2012151.0(0.7–1.4)
  TT781230.7(0.5–1.0)
 Age of diagnosis/selection <65 years
  CC52661.070891.0(0.6–1.6)38341.3(0.7–2.4)
  CT821070.9(0.5–1.4)102921.3(0.8–2.1)
  TT32371.1(0.6–2.0)
 Age of diagnosis/selection 65–79 years
  CC79791.01081280.8(0.5–1.2)55690.8(0.5–1.3)
  CT1291291.1(0.7–1.6)991230.9(0.6–1.3)
  TT46860.6(0.3–0.9)
  P interaction, age category and MTHFR genotype = 0.34
Women
  CC891021.01782061.0(0.7–1.4)601130.6(0.4–0.9)
  CT1712170.9(0.6–1.3)1341840.9(0.6–1.2)
  TT711030.8(0.5–1.2)
 Age of diagnosis/selection <65 years
  CC38471.078721.4(0.8–2.4)21390.7(0.3–1.4)
  CT72881.1(0.6–1.8)52810.9(0.5–1.7)
  TT27381.0(0.5–1.9)
 Age of diagnosis/selection 65–79 years
  CC51551.01001340.8(0.5–1.3)39740.6(0.3–1.0)
  CT991290.8(0.5–1.3)821030.8(0.5–1.4)
  TT44650.7(0.4–1.2)
  P interaction, age category and MTHFR genotype = 0.86
  • a Adjusted for age, body mass index, lifetime vigorous activity, energy intake, dietary fiber, dietary calcium, and usual number of cigarettes smoked. Participants with missing data for any of these variables were excluded (11 men and 10 women).

  • b MTHFR 677/1298 genotypes CT/CC, TT/AC, and TT/CC were not observed in the study population.

  • c OR, odds ratio; CI, confidence interval.