Table 4

Multivariable-adjusteda relative risk [95% confidence interval (CI)] of breast cancer diagnosed anytime after baseline according to quintiles of energy-adjusted glycemic load stratified by physical activity and by menopausal status and physical activity simultaneously

No. of casesQuintile of glycemic loadP for trend
12345
All women, by tertile kJ expended in physical activity
 Lowest tertile physical activity3111.001.25 (0.88–1.78)1.12 (0.75–1.66)1.14 (0.74–1.75)1.24 (0.75–2.04)0.53
 Middle tertile physical activity3051.000.92 (0.63–1.34)0.70 (0.46–1.07)0.84 (0.54–1.29)1.00 (0.61–1.65)>0.99
 Highest tertile physical activity2811.000.72 (0.47–1.09)0.98 (0.65–1.46)0.74 (0.47–1.16)0.77 (0.46–1.29)0.39
Premenopausal women, by tertile kJ expended in physical activity
 Lowest tertile physical activity1191.001.60 (0.91–2.84)1.52 (0.79–2.91)1.62 (0.79–3.34)2.35 (1.03–5.37)0.07
 Middle tertile physical activity1201.000.93 (0.50–1.72)0.77 (0.39–1.54)1.02 (0.50–2.09)1.48 (0.66–3.33)0.28
 Highest tertile physical activity991.000.35 (0.17–0.71)0.67 (0.36–1.27)0.61 (0.31–1.23)0.49 (0.21–1.16)0.22
Postmenopausal women, by tertile kJ expended in physical activity
 Lowest tertile physical activity1921.001.07 (0.68–1.69)0.93 (0.56–1.54)0.91 (0.53–1.56)0.84 (0.45–1.57)0.50
 Middle tertile physical activity1851.000.93 (0.58–1.50)0.69 (0.40–1.17)0.75 (0.43–1.30)0.79 (0.42–1.51)0.40
 Highest tertile physical activity1821.001.18 (0.68–2.05)1.41 (0.81–2.44)0.95 (0.51–1.75)1.12 (0.57–2.21)0.97
  • a Multivariable model was adjusted for age, body mass index, alcohol, smoking, age at menarche, age at first pregnancy, number of pregnancies, oral contraceptive use, postmenopausal hormone use, family history of breast cancer, physical activity, total energy, energy-adjusted total fat, energy-adjusted total fiber, and energy-adjusted folate.