Table 3

Distribution of C282Y genotypes in the transplant cohort by diagnosis

DiagnosisHFE genotypeTotalP (trend)
Wt/Wt n = 132 (n, %)aC282Y/Wt n = 25 (n, %)aC282Y/C282Y n = 11 (n, %)a
Breast cancers26 (20)b10 (40)5 (45)b41c0.010
Hematological cancers0.040
 Acute leukemias22 (17)b6 (24)3 (27)b31c
 Chronic leukemias28 (21)2 (8)1 (9)31
 Myelodysplasia7 (5)1 (4)0 (0)8
 Multiple myeloma12 (9)0 (0)1 (9)13
 Non-Hodgkin lymphoma25 (19)5 (20)1 (9)31
 Hodgkin disease10 (8)1 (4)1 (9)12
  (Subtotal)(104)(15)(7)(126)c
Miscellaneousd
 Aplastic anemia1 (<1)001
 Germ cell cancer2 (<2)002
  (Subtotal)(2)(0)(0)(3)
  (Total cancers)(170)c
  • a Percentage of patients in each genotype category with the indicated diagnosis.

  • b Each of these categories includes 1 patient with both breast cancer and leukemia.

  • c Includes 2 patients with both breast cancer and leukemia.

  • d Insufficient number for analysis.