Table 3

Combinations of at-risk genotypes for GSTM1, GSTP1, and GSTT1 in relation to breast cancer: Shanghai Breast Cancer Study

GSTM1GSTT1GSTP1No. of case subjects (n = 1132)No. of control subjects (n = 1193)OR (95% CI)a
All putative low-risk genotypes
 PresentPresentIle/Ile genotype1541631.0 (referent)
One putative high-risk genotype
 NullPresentIle/Ile2072380.90 (0.67–1.20)
 PresentNullIle/Ile1601730.95 (0.70–1.30)
 PresentPresentIle/Val or Val/Val911000.91 (0.63–1.31)
Two putative high-risk genotypes
 NullNullIle/Ile1982210.91 (0.68–1.23)
 NullPresentIle/Val or Val/Val1251021.30 (0.92–1.83)
 PresentNullIle/Val or Val/Val92801.21 (0.83–1.76)
All three putative high-risk genotypes
 NullNullIle/Val or Val/Val1051160.89 (0.63–1.26)
  • a OR, age-adjusted odds ratio; CI, confidence interval; GST, glutathione S-transferase.