Table 2

Polymorphisms of GSTM1, GSTP1, and GSTT1 and breast cancer risk, Shanghai Breast Cancer Study, 1996–1998

No. of case subjects (%)No. of control subjects (%)All women (n = 2365)Premenopausal (n = 1563)Postmenopausal (n = 757)
Odds Ratio (95% CI)a
GSTM1
 Present497 (43.8)523 (43.4)1.0 (ref)1.0 (ref)1.0 (ref)
 null638 (56.2)683 (56.6)0.97 (0.82, 1.14)0.90 (0.74, 1.11)1.05 (0.79, 1.40)
 missing58104
GSTP1
 Ile/Ile723 (63.5)809 (66.8)1.0 (ref)1.0 (ref)1.0 (ref)
 Ile/Val363 (31.9)371 (30.6)1.08 (0.91, 1.29)1.02 (0.82, 1.27)1.14 (0.83, 1.57)
 Val/Val53 (4.6)31 (2.6)1.92 (1.21, 3.04)2.12 (1.21, 3.71)1.96 (0.82, 4.71)
 missing5499
P, trend0.020.090.15
GSTT1
 Present579 (51.0)614 (50.7)1.0 (ref)1.0 (ref)1.0 (ref)
 null557 (49.0)596 (49.3)0.97 (0.83, 1.15)1.00 (0.82, 1.23)0.95 (0.71, 1.28)
 missing57100
  • a OR, odds ratio adjusted for age; CI, confidence interval. Menopause information was missing for 45 women.