Table 2

MTHFR genotype frequencies and adjusted odds ratios (ORs) for breast cancer among Chinese women, Shanghai Breast Cancer Study, 1996–1998

GenotypeaCases, n (%)Controls, n (%)Age-adjusted OR (95% confidence interval)Multi-adjusted OR (95% confidence interval)
C677T
CC374 (33.6)387 (33.4)1.00 (reference)1.00 (reference)
CT555 (49.9)577 (49.7)1.00 (0.83–1.20)1.01 (0.84–1.22)
TT183 (16.5)196 (16.9)0.97 (0.76–1.24)0.97 (0.76–1.25)
A1298C
AA768 (68.5)824 (68.2)1.00 (reference)1.00 (reference)
AC311 (27.7)344 (28.5)0.97 (0.81–1.16)0.96 (0.80–1.16)
CC42 (3.8)40 (3.3)1.13 (0.72–1.75)1.14 (0.73–1.79)
Combined
A1298C-AA
  C677T-CC196 (18.0)180 (15.9)1.00 (reference)1.00 (reference)
  C677T-CT375 (34.4)410 (36.2)0.84 (0.66–1.07)0.85 (0.66–1.09)
  C677T-TT179 (16.4)184 (16.3)0.89 (0.67–1.19)0.89 (0.67–1.20)
A1298C-AC/CC
  C677T-CC171 (15.7)203 (17.9)0.77 (0.58–1.03)0.77 (0.57–1.02)
  C677T-CT/TT168 (15.4)155 (13.7)0.99 (0.74–1.34)1.01 (0.75–1.36)
  • a The frequencies of the 677T allele were 41.4% in cases and 41.8% in controls (P = 0.81) and the frequencies of the 1298C allele were 17.6% in cases and 17.5% in controls (P = 0.95).

  • b All ORs are adjusted for age, waist-to-hip ratio, age at first live birth, physical activity, menopausal status, and total meat intake.