Table 5

Adjusteda geometric means (95% confidence intervals) of various sex hormones in postmenopausal women, stratified by CYP19 (TTTA) repeat and 3-bp deletion alleles

7r Allele7r(−3) Allele
NoneOne or twoNoneOneTwoP-trend
(n = 128)(n = 43)(n = 70)(n = 85)(n = 16)
Estrone (pg/ml)43.544.947.442.9b35.1c<0.001
(41.1–46.0)(41.1–49.1)(44.2–50.9)(40.0–46.1)(31.0–39.7)
Estradiol (pg/ml)18.117.618.917.915.3c0.03
(17.1–19.2)(16.2–19.2)(17.5–20.4)(16.7–19.1)(13.3–17.7)
Free estradiol (pg/ml)0.480.490.520.47b0.40c0.005
(0.46–0.52)(0.45–0.53)(0.48–0.57)(0.44–0.51)(0.34–0.48)
SHBGd (nmol/liter)35.932.632.136.9c39.0b0.01
(33.6–38.4)(28.4–37.4)(29.5–34.8)(33.6–40.6)(32.8–46.4)
2-Hydroxyestronee (ng/mg creatinine)7.05.96.46.87.40.37
(6.3–7.8)(4.8–7.3)(5.4–7.5)(6.0–7.8)(5.0–11.1)
16α-Hydroxyestronee (ng/mg creatinine)6.05.45.46.07.00.09
(5.4–6.6)(4.4–6.6)(4.7–6.2)(5.3–6.7)(5.2–9.4)
Androstenedione (pg/ml)571514525596c4980.54
(534–610)(457–578)(477–577)(550–646)(402–618)
Testosterone (pg/ml)219210198235c2070.11
(205–234)(185–238)(180–218)(216–256)(171–249)
Free testosterone (pg/ml)4.74.74.54.94.30.61
(4.4–5.0)(4.2–5.3)(4.1–4.8)(4.5–5.4)(3.4–5.4)
8r Allele11r Allele
NoneOne or twoNoneOneTwoP-trend
(n = 136)(n = 35)(n = 69)(n = 83)(n = 19)
Estrone (pg/ml)42.350.6c42.445.542.50.51
(40.2–44.5)(45.5–56.2)(39.3–45.8)(42.4–48.9)(37.3–48.3)
Estradiol (pg/ml)17.420.5c17.518.517.80.53
(16.6–18.3)(18.0–23.3)(16.1–18.9)(17.3–19.8)(15.4–20.5)
Free estradiol (pg/ml)0.470.56c0.470.490.500.45
(0.44–0.49)(0.49–0.65)(0.43–0.52)(0.46–0.53)(0.43–0.58)
SHBG (nmol/liter)35.931.834.636.231.70.74
(33.6–38.4)(27.8–36.4)(31.2–38.3)(32.9–40.1)(28.7–35.0)
2-Hydroxyestronee (ng/mg creatinine)6.96.16.96.66.50.60
(6.2–7.6)(5.0–7.5)(5.9–8.1)(5.7–7.6)(5.1–8.3)
16α-Hydroxyestronee (ng/mg creatinine)6.05.06.05.85.10.36
(5.5–6.6)(4.1–6.2)(5.2–6.9)(5.2–6.6)(4.1–6.5)
Androstenedione (pg/ml)5495855475715310.94
(516–584)(508–674)(494–605)(530–616)(435–648)
Testosterone (pg/ml)2152232192221870.38
(202–228)(188–264)(196–244)(206–240)(154–227)
Free testosterone (pg/ml)4.65.04.84.74.30.51
(4.3–4.9)(4.3–5.8)(4.3–5.3)(4.4–5.1)(3.6–5.2)
  • a Adjusted for CYP17, CYP1B1, COMT, age, kilograms of body fat, oophorectomy status, race, ever used hormone therapy, ever used herbal hormones, marital status, and alcohol consumption.

  • b P ≤ 0.10, compared with no copies of that allele.

  • c P ≤ 0.05, compared with no copies of that allele.

  • d SHBG, sex hormone-binding globulin.

  • e Urinary hormone.