Table 4

Adjusteda geometric means (95% confidence intervals) of various sex hormones in postmenopausal women, stratified by CYP17 genotype

A1/A1 (n = 61)A1/A2 (n = 78)A2/A2 (n = 32)P-trend
Estrone (pg/ml)42.945.242.40.43
(40.2–45.8)(42.2–48.5)(37.1–48.5)
Estradiol (pg/ml)17.818.617.10.74
(16.7–19.0)(17.2–20.0)(15.2–19.1)
Free estradiol (pg/ml)0.500.490.450.21
(0.46–0.53)(0.46–0.53)(0.39–0.51)
SHBGc (nmol/liter)30.937.1b39.0b0.005
(27.8–34.4)(34.1–40.2)(33.9–44.9)
2-Hydroxyestroned (ng/mg creatinine)5.97.1e7.50.06
(5.1–6.8)(6.1–8.2)(5.8–9.8)
16α-Hydroxyestroned (ng/mg creatinine)5.56.06.20.33
(4.7–6.4)(5.3–6.7)(5.0–7.7)
Androstenedione (ng/ml)5565635410.86
(513–602)(519–612)(446–656)
Testosterone (pg/ml)2142182170.84
(192–238)(200–238)(186–253)
Free testosterone (pg/ml)4.94.64.50.33
(4.4–5.4)(4.2–5.0)(3.9–5.2)
DHEA (ng/ml)2.52.22.10.20
(2.2–2.8)(2.0–2.5)(1.7–2.7)
DHEAS (μg/dl)60.456.251.30.32
(50.1–72.9)(48.4–65.3)(38.5–68.2)
  • a Adjusted for CYP19 7r(−3), CYP1B1, CYP1B1, COMT, age, kilograms of body fat, oophorectomy status, race, ever used hormone therapy, ever used herbal hormones, marital status, and alcohol consumption.

  • b P ≤ 0.05, compared with A1/A1.

  • c SHBG, sex hormone-binding globulin; DHEA, dehydroepiandrosterone; DHEAS, dehydroepiandrosterone sulfate.

  • d Urinary hormone.

  • e P ≤ 0.10, compared with A1/A1.