Table 4

Adjusteda geometric means (95% confidence intervals) of various sex hormones in postmenopausal women, stratified by CYP17 genotype

A1/A1 (n = 61)A1/A2 (n = 78)A2/A2 (n = 32)P-trend
Estrone (pg/ml)42.945.242.40.43
Estradiol (pg/ml)17.818.617.10.74
Free estradiol (pg/ml)0.500.490.450.21
SHBGc (nmol/liter)30.937.1b39.0b0.005
2-Hydroxyestroned (ng/mg creatinine)5.97.1e7.50.06
16α-Hydroxyestroned (ng/mg creatinine)
Androstenedione (ng/ml)5565635410.86
Testosterone (pg/ml)2142182170.84
Free testosterone (pg/ml)
DHEA (ng/ml)
DHEAS (μg/dl)60.456.251.30.32
  • a Adjusted for CYP19 7r(−3), CYP1B1, CYP1B1, COMT, age, kilograms of body fat, oophorectomy status, race, ever used hormone therapy, ever used herbal hormones, marital status, and alcohol consumption.

  • b P ≤ 0.05, compared with A1/A1.

  • c SHBG, sex hormone-binding globulin; DHEA, dehydroepiandrosterone; DHEAS, dehydroepiandrosterone sulfate.

  • d Urinary hormone.

  • e P ≤ 0.10, compared with A1/A1.