Table 1.

Multivariable-adjusted geometric mean hormone levels by CYP17, CYP19, and HSD17-B1 genotypes

Menopausal statusn (%)Estradiol (pmol/L), tmean (95% confidence interval)P for heterogeneity/trend
Premenopausal*
CYP17TT204 (38.9)362 (338-387)0.6/0.7
TC244 (46.6)346 (326-368)
CC76 (14.5)359 (321-401)
Postmenopausal
CYP17TT174 (42.2)18.1 (16.8-19.6)0.7/0.5
TC181 (43.9)18.3 (16.9-19.7)
CC57 (13.8)19.4 (16.9-22.1)
CYP197/773 (21.0)18.9 (16.9-21.1)0.9/9
7/838 (10.9)17.9 (15.3-21.0)
7/11125 (35.9)17.5 (16.1-19.1)
8/1119 (5.5)18.8 (15.1-23.5)
11/1153 (15.2)17.5 (15.3-20.0)
Other40 (11.5)19.0 (16.3-22.2)
CYP19 TCTIns/Ins158 (45.4)18.2 (16.9-19.7)0.8/1.0
Ins/Del154 (44.3)17.7 (16.4-19.2)
Del/Del36 (10.3)18.9 (16.0-22.2)
CYP19 exon 10CC76 (19.6)18.8 (16.8-21.1)0.7/0.4
CT196 (50.5)18.2 (17.0-19.5)
TT116 (29.9)17.8 (16.3-19.6)
HSD17-B1GG68 (51.7)18.3 (16.2-20.7)0.9/0.8
AG193 (18.2)18.1 (16.9-19.5)
AA112 (30.0)18.6 (16.9-20.4)
Postmenopausal
No. high-risk alleles03 (0.9)20.6 (11.7-36.2)1.0/0.6
138 (10.8)18.3 (15.6-21.4)
289 (25.3)17.8 (16.0-19.8)
3106 (30.1)17.5 (15.9-19.2)
479 (22.4)18.8 (16.8-21.0)
530 (8.5)18.9 (15.8-22.5)
67 (2.0)19.5 (13.5-28.3)
  • * Adjusted for age group, body mass index, day of cycle (grouped), hours since last meal, smoking, vigorous exercise, and alcohol consumption.

  • Adjusted for age group, body mass index, vigorous exercise, and days blood sample was in the post.

  • No. high-risk alleles from CYP17 (C allele), CYP19 exon 10 (T allele), and HSD17-B1 (A allele).