Table 1.

Association between MTHFR C677T and A1298C genotypes and chronic lymphocytic leukemia risk

Cases (n)Controls (n)OR95% CI
MTHFR C677T
    CC3613831.0*
    CT3813971.02(0.83-1.24)
    TT901060.90(0.66-1.24)
MTHFR A1298C
    AA3974121.0*
    AC3633890.97(0.79-1.18)
    CC72850.88(0.62-1.24)
MTHFR C677T/A1298C
    CC/AA1181071.0*,,
    CC/AC1711910.81(0.58-1.13)
    CC/CC72850.77(0.51-1.16)
    CT/AA1891990.86(0.62-1.20)
    CT/AC1921980.88(0.63-1.22)
    TT/AA901060.77(0.52-1.13)
  • NOTE: Unadjusted ORs and 95% CIs are shown for 832 cases and 886 controls; adjusting for age and sex was not significant. MTHFR 677/1298 genotypes CT/CC, TT/AC, and TT/CC were not observed in this study.

  • * Reference group.

  • Ptrend = 0.18; 1298 AA/AC/CC within 677CC.

  • Ptrend = 0.18; 677 CC/CT/TT within 1298AA.